Titre du document / Document title
Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy
Auteur(s) / Author(s)
BLAIR S. N. ;
CAPUZZI D. M. ;
GOTTLIEB S. O. ;
NGUYEN T. ;
MORGAN J. M. ;
CATER N. B. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
Cooper Institute, Dallas, Texas, ETATS-UNIS
Jefferson Medical College, Philadelphia, Pennsylvania, ETATS-UNIS
Midatlantic Cordiovascular Associates, Baltimore, Maryland, ETATS-UNIS
Mayo Clinic, Rochester, Minnesota, ETATS-UNIS
University of Texas Southwestern Medical Center, Dallas, Texas, ETATS-UNIS
Résumé / Abstract
This study compares the effect of plant stanol ester spread with a placebo spread on cholesterol in patients taking statin therapy, but who still had elevated low-density lipoprotein (LDL) cholesterol. This was a randomized, double-blind, placebo-controlled clinical trial, with 67 women and 100 men with LDL cholesterol ≥130 mg/dl and triglycerides ≤350 mg/dl who had been taking a stable dose of a statin drug for at least 90 days before the start of the study. For 8 weeks, participants consumed 3 servings/day of the plant stanol ester spread that provided 5.1 g/day of plant stanol ester or a placebo. The addition of plant stanol ester spread significantly reduced total cholesterol and LDL cholesterol at 2, 4, and 8 weeks when compared with placebo spread. Plant stanol ester spread reduced total cholesterol at 8 weeks by 12% compared with a placebo reduction of 5% (-7% difference; p <0.0001). Plant stanol ester spread reduced LDL cholesterol at 8 weeks by 17% compared with a 7% reduction in the placebo group (-10% difference, p <0.0001). The absolute reduction in LDL cholesterol at 8 weeks was 24 and 10 mg/dl in the stanol ester and placebo groups, respectively. The plant stanol ester spread group also had greater reductions in both serum total cholesterol and LDL cholesterol than the placebo group at 2 and 4 weeks (p <0.001 for all comparisons). Both spreads were well tolerated by study participants, and no significant adverse events were noted. Consumption of spread that provided 5.1 g/day of plant stanol esters effectively reduced elevated total and LDL cholesterol levels in participants on a stable regimen of a statin.
Revue / Journal Title
The American journal of cardiology
ISSN
0002-9149
CODEN AJCDAG
Source / Source
2000, vol. 86, n
o1, pp. 46-52 (21 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS
(1958)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 8674, 35400009028771.0090
Nº notice refdoc (ud4) : 1426830
