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Titre du document / Document title

Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy

Auteur(s) / Author(s)

BLAIR S. N. ; CAPUZZI D. M. ; GOTTLIEB S. O. ; NGUYEN T. ; MORGAN J. M. ; CATER N. B. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Cooper Institute, Dallas, Texas, ETATS-UNIS
Jefferson Medical College, Philadelphia, Pennsylvania, ETATS-UNIS
Midatlantic Cordiovascular Associates, Baltimore, Maryland, ETATS-UNIS
Mayo Clinic, Rochester, Minnesota, ETATS-UNIS
University of Texas Southwestern Medical Center, Dallas, Texas, ETATS-UNIS

Résumé / Abstract

This study compares the effect of plant stanol ester spread with a placebo spread on cholesterol in patients taking statin therapy, but who still had elevated low-density lipoprotein (LDL) cholesterol. This was a randomized, double-blind, placebo-controlled clinical trial, with 67 women and 100 men with LDL cholesterol ≥130 mg/dl and triglycerides ≤350 mg/dl who had been taking a stable dose of a statin drug for at least 90 days before the start of the study. For 8 weeks, participants consumed 3 servings/day of the plant stanol ester spread that provided 5.1 g/day of plant stanol ester or a placebo. The addition of plant stanol ester spread significantly reduced total cholesterol and LDL cholesterol at 2, 4, and 8 weeks when compared with placebo spread. Plant stanol ester spread reduced total cholesterol at 8 weeks by 12% compared with a placebo reduction of 5% (-7% difference; p <0.0001). Plant stanol ester spread reduced LDL cholesterol at 8 weeks by 17% compared with a 7% reduction in the placebo group (-10% difference, p <0.0001). The absolute reduction in LDL cholesterol at 8 weeks was 24 and 10 mg/dl in the stanol ester and placebo groups, respectively. The plant stanol ester spread group also had greater reductions in both serum total cholesterol and LDL cholesterol than the placebo group at 2 and 4 weeks (p <0.001 for all comparisons). Both spreads were well tolerated by study participants, and no significant adverse events were noted. Consumption of spread that provided 5.1 g/day of plant stanol esters effectively reduced elevated total and LDL cholesterol levels in participants on a stable regimen of a statin.

Revue / Journal Title

The American journal of cardiology    ISSN  0002-9149   CODEN AJCDAG 

Source / Source

2000, vol. 86, no1, pp. 46-52 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1958) (Revue)

Mots-clés anglais / English Keywords

Dyslipemia

;

Cholesterol LDL

;

Human

;

Enzyme inhibitor

;

Hydroxymethylglutaryl-CoA reductase

;

Combined treatment

;

Ester

;

Plant origin

;

Chemotherapy

;

Treatment

;

Treatment efficiency

;

Lipids

;

Oxidoreductases

;

Enzyme

;

Metabolic diseases

;

Antilipemic agent

;

Mots-clés français / French Keywords

Dyslipémie

;

Cholestérol LDL

;

Homme

;

Inhibiteur enzyme

;

Hydroxymethylglutaryl-CoA reductase

;

Traitement associé

;

Ester

;

Origine végétale

;

Chimiothérapie

;

Traitement

;

Efficacité traitement

;

Lipide

;

Stanol ester

;

Oxidoreductases

;

Enzyme

;

Métabolisme pathologie

;

Hypolipémiant

;

Mots-clés espagnols / Spanish Keywords

Dislipemia

;

Colesterol LDL

;

Hombre

;

Inhibidor enzima

;

Hydroxymethylglutaryl-CoA reductase

;

Tratamiento asociado

;

Ester

;

Origen vegetal

;

Quimioterapia

;

Tratamiento

;

Eficacia tratamiento

;

Lípido

;

Oxidoreductases

;

Enzima

;

Metabolismo patología

;

Hipolipemiante

;

Localisation / Location

INIST-CNRS, Cote INIST : 8674, 35400009028771.0090

Nº notice refdoc (ud4) : 1426830



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