Titre du document / Document title
Long-term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a quantitative review
Auteur(s) / Author(s)
KNEYBER M. C. J. (1) ;
STEYERBERG E. W. (2) ;
DE GROOT R. (1) ;
MOLL H. A. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Paediatrics, Sophia Children's Hospital Rotterdam/University Hospital Rotterdam, PAYS-BAS
(2) Department of Public Health, Erasmus University Rotterdam, PAYS-BAS
Résumé / Abstract
One of the major questions regarding long-term side effects of bronchiolitis by respiratory syncytial virus (RSV) is whether or not it induces asthma in later life. In this quantitative review, the data of 10 controlled studies are analysed. Methods: Follow-up studies of RSV bronchiolitis published between January 1978 and December 1998 were identified through a MEDLINE search. Studies were selected if (i) postnatal age at the time of the inital illness was below 12 mo, (ii) all children were hospitalized for RSV bronchiolitis, (iii) the diagnosis RSV was virologically confirmed in all cases, and (iv) a control group was used. Results: Six studies met all selection criteria. Up to 5 y of follow-up after RSV bronchiolitis in infancy, 40% of children reported wheezing as compared to only 11% in the control group (p < 0.001). Between 5 and 10 y of follow-up 22% of the bronchiolitis group reported wheezing against 10% of the control group (p=0.19). The incidence of recurrent wheezing as defined by three or more wheezing episodes also decreased with increasing years of follow-up: at 5 or more years of follow-up the difference between the RSV group and the control group was no longer significant. Furthermore, the presence of either a personal and/or a family history of either atopy and/or asthma did not differ between the two groups. Conclusions; Wheezing is common after RSV bronchiolitis in infancy. It may persist for >5 y of follow-up. However, no significant difference between the RSV bronchiolitis and the control group was observed regarding recurrent wheezing by 5 y of follow-up. No significant difference between the RSV bronchiolitis and the control group were found regarding a personal history of atopy, a family history of atopy and/or asthma. Therefore it seems unlikely that RSV bronchiolitis is a cause of atopic asthma in later life.
Revue / Journal Title
Acta paediatrica
ISSN
0803-5253
Source / Source
2000, vol. 89, n
o6, pp. 654-660 (31 ref.)
Langue / Language
Anglais
Editeur / Publisher
Blackwell, Oxford, ROYAUME-UNI
(1992)
(Revue)
Mots-clés anglais / English Keywords
Bronchiolitis ;
Human respiratory syncytial virus ;
Viral disease ;
Child ;
Asthma ;
Prognosis ;
Long term ;
Atopy ;
Pneumovirus ;
Pneumovirinae ;
Paramyxoviridae ;
Mononegavirales ;
Virus ;
Infection ;
Human ;
Respiratory disease ;
Bronchus disease ;
Obstructive pulmonary disease ;
Immunopathology ;
Allergy ;
Mots-clés français / French Keywords
Bronchiolite ;
Virus respiratoire syncytial humain ;
Virose ;
Enfant ;
Asthme ;
Pronostic ;
Long terme ;
Atopie ;
Pneumovirus ;
Pneumovirinae ;
Paramyxoviridae ;
Mononegavirales ;
Virus ;
Infection ;
Homme ;
Appareil respiratoire pathologie ;
Bronche pathologie ;
Bronchopneumopathie obstructive ;
Immunopathologie ;
Allergie ;
Mots-clés espagnols / Spanish Keywords
Bronquiolitis ;
Human respiratory syncytial virus ;
Virosis ;
Niño ;
Asma ;
Pronóstico ;
Largo plazo ;
Atopía ;
Pneumovirus ;
Pneumovirinae ;
Paramyxoviridae ;
Mononegavirales ;
Virus ;
Infección ;
Hombre ;
Aparato respiratorio patología ;
Bronquio patología ;
Broncopneumopatía obstructiva ;
Inmunopatología ;
Alergia ;
Localisation / Location
INIST-CNRS, Cote INIST : 944, 35400009004384.0070
Nº notice refdoc (ud4) : 1418944
