Titre du document / Document title

Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance

Auteur(s) / Author(s)

CHOPRA Ian ⁽¹⁾ ; ROBERTS Marilyn ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Antimicrobial Research Centre and Division of Microbiology, School of Biochemistry & Molecular Biology, University of Leeds, Leeds LS2 9JT, ROYAUME-UNI
⁽²⁾ Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195-72382, ETATS-UNIS

Résumé / Abstract

Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy of human and animal infections and also at subtherapeutic levels in animal feed as growth promoters. The first tetracycline-resistant bacterium, Shigella dysenteriae, was isolated in 1953. Tetracycline resistance now occurs in an increasing number of pathogenic, opportunistic, and commensal bacteria. The presence of tetracycline-resistant pathogens limits the use of these agents in treatment of disease. Tetracycline resistance is often due to the acquisition of new genes, which code for energy-dependent efflux of tetracyclines or for a protein that protects bacterial ribosomes from the action of tetracyclines. Many of these genes are associated with mobile plasmids or transposons and can be distinguished from each other using molecular methods including DNA-DNA hybridization with oligonucleotide probes and DNA sequencing. A limited number of bacteria acquire resistance by mutations, which alter the permeability of the outer membrane porins and/or lipopolysaccharides in the outer membrane, change the regulation of innate efflux systems, or alter the 16S rRNA. New tetracycline derivatives are being examined, although their role in treatment is not clear. Changing the use of tetracyclines in human and animal health as well as in food production is needed if we are to continue to use this class of broad-spectrum antimicrobials through the present century.

Revue / Journal Title

Microbiology and molecular biology reviews   ISSN 1092-2172   CODEN MMBRF7 

Source / Source

2001, vol. 65, n^o2, pp. 232-260 [30 page(s) (article)] (319 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Society for Microbiology, Washington, DC, ETATS-UNIS  (1997) (Revue)

Mots-clés anglais / English Keywords

Enterobacteriaceae ; Bacteria ; Mollicutes ; Mycoplasmatales ; Mycoplasmataceae ; Therapy ; Parasite ; Human ; Treatment ; Tetracycline derivatives ; Gram positive bacteria ; Resistance ; Gram negative bacteria ; Molecular biology ; Molecular epidemiology ; Application ; Mechanism of action ; Antibiotic ; Shigella dysenteriae ; Protozoa ; Mycoplasma ; Microorganism ;

Mots-clés français / French Keywords

Enterobacteriaceae ; Bactérie ; Mollicutes ; Mycoplasmatales ; Mycoplasmataceae ; Thérapie ; Parasite ; Homme ; Traitement ; Tétracycline dérivé ; Bactérie Gram positif ; Résistance ; Bactérie Gram négatif ; Biologie moléculaire ; Epidémiologie moléculaire ; Application ; Mécanisme action ; Antibiotique ; Shigella dysenteriae ; Protozoa ; Mycoplasma ; Microorganisme ;

Mots-clés espagnols / Spanish Keywords

Enterobacteriaceae ; Bacteria ; Mollicutes ; Mycoplasmatales ; Mycoplasmataceae ; Terapia ; Parásito ; Hombre ; Tratamiento ; Tetraciclina derivado ; Bacteria Gram positiva ; Resistencia ; Bacteria Gram negativa ; Biología molecular ; Epidemiología molecular ; Aplicación ; Mecanismo acción ; Antibiótico ; Shigella dysenteriae ; Protozoa ; Mycoplasma ; Microorganismo ;

Localisation / Location

INIST-CNRS, Cote INIST : 2044 A, 35400009834814.0030