Titre du document / Document title

Five-week, low-glycemic index diel decreases total fat mass and improves plasma lipid profile in moderately overweight nondiabetic men

Auteur(s) / Author(s)

BOUCHE Clara ⁽¹⁾ ; RIZKALLA Salwa W. ⁽¹⁾ ; JING LUO ⁽¹⁾ ; VIDAL Hubert ⁽²⁾ ; VERONESE Annie ⁽¹⁾ ; PACHER Nathalie ⁽¹⁾ ; FOUQUET Caroline ⁽¹⁾ ; LANG Vincent ⁽³⁾ ; SLAMA Gérard ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 341, Department of Diabetes, AP Hôtel-Dieu Hospital, Paris, FRANCE
⁽²⁾ INSERM Unit 449, Lyon, FRANCE
⁽³⁾ Danone Vitapole, Le Plessis Robinson, FRANCE

Résumé / Abstract

OBJECTIVE - To evaluate whether a 5-week low-glycemic index (LGI) diet versus a high-glycemic index (HGI) diet can modify glucose and lipid metabolism as well as total fat mass in nondiabetic men RESEARCH DESIGN AND METHODS In this study, 11 healthy men were randomly allocated to 5 weeks of an LGl or HGI diet separated by a 5-week washout interval in a crossover design RESULTS - The LGI diet resulted in lower postprandial plasma glucose and insulin profiles and areas under the curve (AUCs) than the HGI diet A 5-week period of the LGI diet lowered plasma triacylglycerol excursion after lunch (AUC, P < 0.05 LGI vs. HGI). These modifications were associated with a decrease in the total fat mass by ∼700 g (P < 0.05) and a tendency to increase lean body mass (P < 0.07) without any change in body weight This decrease in fat mass was accompanied by a decrease in leptin, lipoprotein lipase, and hormone-sensitive lipase RNAm quantities in the subcutaneous abdominal adipose tissue (P < 0.05) CONCLUSIONS - We concluded that 5 weeks of an LGI diet ameliorates some plasma lipid parameters, decreases total fat mass, and tends to increase lean body mass without changing body weight. These changes were accompanied by a decrease in the expression of some genes implicated in lipid metabolism. Such a diet could be of benefit to healthy, slightly overweight subjects and might play a role in the prevention of metabolic diseases and their cardiovascular complications.

Revue / Journal Title

Diabetes care   ISSN 0149-5992   CODEN DICAD2 

Source / Source

2002, vol. 25, n^o5, pp. 822-828 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Diabetes Association, Alexandria, VA, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Glycemic index ; Cardiovascular disease ; Metabolic diseases ; Glucose ; Comparative study ; Diet ; Human ; Lipids ; Blood plasma ; Fat mass ; Triacylglycerol ; Insulin ; Postprandial ; Overweight ; Adipose tissue ;

Mots-clés français / French Keywords

Indice glycémique ; Maladie cardiovasculaire ; Métabolisme pathologie ; Glucose ; Etude comparative ; Régime alimentaire ; Homme ; Lipide ; Plasma sanguin ; Masse grasse ; Triacylglycérol ; Insuline ; Postprandial ; Surcharge pondérale ; Tissu adipeux ;

Mots-clés espagnols / Spanish Keywords

Cardiovascular enfermedad ; Metabolismo patología ; Glucosa ; Estudio comparativo ; Régimen alimentario ; Hombre ; Lípido ; Plasma sanguíneo ; Masa grasa ; Triacilglicerol ; Insulina ; Postprandial ; Sobrecarga ponderal ; Tejido adiposo ;

Localisation / Location

INIST-CNRS, Cote INIST : 18054, 35400010825199.0030