Titre du document / Document title

Toxic endothelial cell destruction from intraocular benzalkonium chloride

Auteur(s) / Author(s)

LIU Henry ⁽¹⁾ ; ROUTLEY Ian ⁽²⁾ ; TEICHMANN Klaus D. ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Orana Eye Centre, Dubbo, New South Wales, AUSTRALIE
⁽²⁾ Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, AUSTRALIE
⁽³⁾ El-Maghraby Eye & Ear Hospital, Jeddah, ARABIE SAOUDITE

Résumé / Abstract

Purpose: To present a cluster of cases of corneal edema occurring after phacoemulsification. Setting: Regional hospital in rural Australia. Methods: This retrospective case series comprised 12 patients from a single surgical list comprising 19 cases who developed persistent corneal edema after having phacoemulsification. Results: After 6 months, the edema improved in 1 patient. Inadvertent intraocular use of balanced salt solution (BSS®) preserved with benzalkonium chloride was found to be the cause of this serious complication. Conclusions: Benzalkonium chloride in concentrations commonly used extraocularly is highly toxic to the corneal endothelium. Every possible safeguard should be taken to prevent inadvertent intraocular use of such preserved solutions.

Revue / Journal Title

Journal of cataract and refractive surgery   ISSN 0886-3350   CODEN JCSUEV 

Source / Source

2001, vol. 27, n^o11, pp. 1746-1750 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1986) (Revue)

Mots-clés anglais / English Keywords

Keratopathy ; Eye disease ; Surgery ; Human ; Intraocular ; Cell death ; Endothelial cell ; Cornea ; Edema ; Isotonic solution ; Preservative ; Benzalkonium chloride ; Treatment ; Toxicity ; Phacoemulsification ;

Mots-clés français / French Keywords

Kératopathie ; Oeil pathologie ; Chirurgie ; Homme ; Intraoculaire ; Mort cellulaire ; Cellule endothéliale ; Cornée ; Oedème ; Solution isotonique ; Conservateur ; Chlorure de benzalkonium ; Traitement ; Toxicité ; Phacoémulsification ;

Mots-clés espagnols / Spanish Keywords

Queratopatía ; Ojo patología ; Cirugía ; Hombre ; Intraocular ; Muerte celular ; Célula endotelial ; Córnea ; Edema ; Solución isotónica ; Conservador ; Cloruro de benzalconio ; Tratamiento ; Toxicidad ; Facoemulsificación ;

Localisation / Location

INIST-CNRS, Cote INIST : 20937, 35400009932261.0060