Titre du document / Document title

Fat consumption and HbA_1c levels : The EPIC-Norfolk Study

Auteur(s) / Author(s)

HARDING Anne-Helen ⁽¹⁾ ; SARGEANT Lincoln A. ⁽¹⁾ ; WELCH Ailsa ⁽¹⁾ ; OAKES Suzy ⁽¹⁾ ; LUBEN Robert N. ⁽¹⁾ ; BINGHAM Sheila ⁽¹⁾ ; DAY Nicholas E. ⁽¹⁾ ; KHAW Kay-Tee ⁽¹⁾ ; WAREHAM Nicholas J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, ROYAUME-UNI

Résumé / Abstract

OBJECTIVE - To describe the relationship between total dietary fat and the pattern of fat intake and HbA_1c. RESEARCH DESIGN AND METHODS - In this cross-sectional study, 2.759 men and 3,464 women (40-78 years of age) without a previous diagnosis of type 2 diabetes were recruited from a population-based sampling frame Diet was assessed using a self-reported semiquantitative food frequency questionnaire. RESULTS - The HbA_1c level was negatively associated with the polyunsaturated lat-to-saturated fat ratio (P:S ratio) of the diet (β = -0.0338 HbA_1c% per SD change in P:S ratio; P < 0.001) and positively associated with the total level of fat intake (β = 0.0620 HbA_1c% per SD change in total fat intake, P < 0.001), adjusted for age and total energy intake. The associations remained significant when adjusted for each other and for total energy, protein, age, sex, family history of diabetes, BMI, waist-to-hip ratio, physical activity, and smoking (for P:S ratio, β = -0.0200 HbA_1c % per SD change in P:S ratio, P = 0.013; for total fat, β = 0.420% HbA_1c% per SD change in total fat intake, P < 0.001). The benefits from a high P:S ratio were attributed to a lower saturated fat intake CONCLUSIONS - These findings demonstrate independent associations between HbA_1c concentration across the normal range of HbA_1c and both total fat intake and the pattern of dietary fat intake.They provide further support to efforts promoting modifications in the intake of dietary fat.

Revue / Journal Title

Diabetes care   ISSN 0149-5992   CODEN DICAD2 

Source / Source

2001, vol. 24, n^o11, pp. 1911-1916 (40 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Diabetes Association, Alexandria, VA, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Endocrinopathy ; Human ; Elderly ; Adult ; Epidemiology ; Risk factor ; Diabetes mellitus ; Blood plasma ; Hemoglobin A1c ; Comparative study ; Quantitative analysis ; Fat ; Food intake ;

Mots-clés français / French Keywords

Endocrinopathie ; Homme ; Personne âgée ; Adulte ; Epidémiologie ; Facteur risque ; Diabète ; Plasma sanguin ; Hémoglobine A1c ; Etude comparative ; Analyse quantitative ; Matière grasse ; Consommation alimentaire ;

Mots-clés espagnols / Spanish Keywords

Endocrinopatía ; Hombre ; Anciano ; Adulto ; Epidemiología ; Factor riesgo ; Diabetes ; Plasma sanguíneo ; Hemoglobina A1c ; Estudio comparativo ; Análisis cuantitativo ; Materia grasa ; Consumo alimenticio ;

Localisation / Location

INIST-CNRS, Cote INIST : 18054, 35400009988552.0110