Titre du document / Document title

Brainstem microstimulation activates sympathetic fibers in pudendal nerve motor branch

Auteur(s) / Author(s)

JOHNSON R. D. ⁽¹⁾ ; HUBSCHER C. H. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Physiological Sciences, College of Veterinary Medicine and the University of Florida Brain Institute, University of Florida, Box 100144, Gainesville, FL 32610-0144, ETATS-UNIS

Résumé / Abstract

A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers containing within the motor branch of the pudendal nerve (PudM). In anesthetized rats, long latency (> 150 ms) discharges were elicited in the PudM following ipsilateral or contralateral microstimulation of the MRF. These firing bursts were not observed in rats after sectioning the lower lumbar sympathetic trunk. The most robust activation was observed when neurons in or near the lateral paragigantocellular reticular nucleus were microstimulated bilaterally. Urogenital dysfunction that occurs following severe spinal cord injury probably results from disrupting these and other supraspinal circuits.

Revue / Journal Title

Neuroreport   ISSN 0959-4965 

Source / Source

2000, vol. 11, n^o2, pp. 379-382 (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams and Wilkins, Hagerstown, MD, ETATS-UNIS  (1990) (Revue)

Mots-clés anglais / English Keywords

Brain stem ; Pudendal nerve ; Motor nerve ; Sympathetic nervous system ; Action potential ; Urogenital system ; Male ; Rattus norvegicus ; Peripheral nervous system ; Electrophysiology ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés français / French Keywords

Tronc cérébral ; Nerf honteux ; Nerf moteur ; Système nerveux sympathique ; Potentiel action ; Appareil urogénital ; Mâle ; Rattus norvegicus ; Muridae ; Système nerveux périphérique ; Electrophysiologie ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés espagnols / Spanish Keywords

Tronco cerebral ; Nervio pudendo ; Nervio motor ; Sistema nervioso simpático ; Potencial acción ; Aparato urogenital ; Macho ; Rattus norvegicus ; Sistema nervioso periférico ; Electrofisiología ; Rodentia ; Mammalia ; Vertebrata ;

Localisation / Location

INIST-CNRS, Cote INIST : 22534, 35400008739428.0310