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Titre du document / Document title

Investigating the properties of novel poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel hollow fiber membranes

Auteur(s) / Author(s)

YING LUO (1 2) ; DALTON Paul D. (1 2) ; SHOICHET Molly S. (1 2 3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, CANADA
(2) Institute of Biomaterials and Biomedical Engineering, University of Toronto, 170 College Street, Toronto, Ontario, M5S 3E3, CANADA
(3) Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 1A1, CANADA

Résumé / Abstract

Poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel hollow fiber membranes were synthesized by a novel centrifugal-spinning methodology that resulted in new asymmetric wall morphologies, which in turn affected the mechanical and transport properties. Hollow fiber membranes were formed after polymerizing the comonomers, 2-hydroxyethyl methacrylate and methyl methacrylate, in an aqueous system under centrifugal forces. The concentration of methyl methacrylate in the comonomer and the concentration of redox initiators were investigated for their effects on membrane morphology, water content, Young's modulus, and diffusive transport. Both monomer composition and initiator concentration impacted the resulting asymmetric membrane morphology, which varied from a macroporous sponge to a microporous gel to a homogeneous gel. The hollow fiber membranes synthesized herein had equilibrium water contents between 42 and 57%, elastic moduli between 22 and 400 kPa, and effective diffusion coefficients between 10-7 and 10-9 cm2 s-1 for vitamin B12 and 10 kD dextran. The significant differences in both the moduli and the diffusion coefficients exhibited by these hydrogel membranes reflect differences in their intrinsic microstructures. Synthesis of hydrogel hollow fiber membranes using centrifugal force is a highly dynamic process; the membrane properties can be effectively tailored by controlling phase separation kinetics. These hydrogel hollow fibers are particularly attractive for soft tissue applications, such as nerve guidance channels, where biocompatibility, mechanical strength, and transport properties are determinants of device performance in vivo.

Revue / Journal Title

Chemistry of materials    ISSN  0897-4756 

Source / Source

2001, vol. 13, no11, pp. 4087-4093 (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Chemical Society, Washington, DC, ETATS-UNIS  (1989) (Revue)

Mots-clés anglais / English Keywords

Transport properties

;

Experimental study

;

Solutes

;

Molecule scattering

;

Mechanical properties

;

Water content

;

Morphology

;

Property processing relationship

;

Structure processing relationship

;

Solvent spinning

;

Colloidal gel

;

Hydroxyethyl methacrylate copolymer

;

Methyl methacrylate copolymer

;

Hollow fiber

;

Membrane

;

Mots-clés français / French Keywords

Propriété transport

;

Filage centrifuge

;

Etude expérimentale

;

Soluté

;

Diffusion molécule

;

Propriété mécanique

;

Teneur eau

;

Morphologie

;

Relation mise en œuvre propriété

;

Relation mise en œuvre structure

;

Filage solvant

;

Gel colloïdal

;

Méthacrylate d'hydroxyéthyle copolymère

;

Méthacrylate de méthyle copolymère

;

Fibre creuse

;

Membrane

;

Mots-clés espagnols / Spanish Keywords

Propiedad transporte

;

Estudio experimental

;

Soluto

;

Difusión molécula

;

Propiedad mecánica

;

Dosis agua

;

Morfología

;

Relación puesta en marcha propiedad

;

Relación puesta en marcha estructura

;

Hilado solvente

;

Gel coloidal

;

Metacrilato de hidroxietilo copolímero

;

Metacrilato de metilo copolímero

;

Fibra hueca

;

Membrana

;

Localisation / Location

INIST-CNRS, Cote INIST : 21957, 35400009423378.0470

Nº notice refdoc (ud4) : 14141312



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