Titre du document / Document title

Melting behavior of pure polyethylene glycol 6000 and polyethylene glycol 6000 in solid dispersions containing diazepam or temazepam: a DSC study

Auteur(s) / Author(s)

VERHEYEN S. ⁽¹⁾ ; AUGUSTIJNS P. ⁽¹⁾ ; KINGET R. ⁽¹⁾ ; VAN DEN MOOTER G. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Laboratorium voor Farmacotechnologie en Biofarmacie, Campus Gasthuisberg O+N, Katholieke Universiteit Leuven, Herestraat 49, K.U. Leuven, Leuven, BELGIQUE

Résumé / Abstract

The purpose of the present study was to investigate the melting behavior of polyethylene glycol 6000 (PEG 6000) as such as well as in solid dispersions containing diazepam or temazepam, prepared by solvent and fusion methods, using differential scanning calorimetry (DSC). It was shown that the melting behavior of pure PEG 6000 is influenced by the crystallization procedure applied. Fusion at 80°C followed by cooling always yielded three different crystal modifications. The rate of cooling (under controlled conditions) was found to have a significant influence on the relative distribution of the three modifications: the lower the cooling rate, the higher the relative amount of the extended modification. Crystallization from organic solution yielded mainly the once folded form. The presence of diazepam and temazepam influenced the relative amount of the different PEG 6000 modifications. Both drugs decreased the formation of the more stable modification, while the formation of the twice folded form was induced. However, in the case of temazepam the contribution of the extended form at higher drug levels increased in dispersions obtained from organic solutions.

Revue / Journal Title

Thermochimica acta   ISSN 0040-6031   CODEN THACAS 

Source / Source

2001, vol. 380, n^o 2 (190 p.)  (16 ref.), pp. 153-164

Langue / Language

Anglais

Revue : Allemand

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1970) (Revue)

Mots-clés anglais / English Keywords

Differential scanning calorimetry ; Thermal analysis ; Ethylene oxide polymer ; Drug adjuvant ; Benzodiazepine derivatives ; Hypnotic ; Psychotropic ; Tranquillizer ; Diazepam ; Temazepam ; Solid dispersion ; Solid form ; Dosage form ;

Mots-clés français / French Keywords

Calorimétrie différentielle balayage ; Analyse thermique ; Ethylène oxyde polymère ; Adjuvant médicamenteux ; Benzodiazépine dérivé ; Hypnotique ; Psychotrope ; Tranquillisant ; Diazépam ; Témazépam ; Dispersion solide ; Forme solide ; Forme pharmaceutique ;

Mots-clés espagnols / Spanish Keywords

Análisis calorimétrico barrido exploración ; Análisis térmico ; Etileno óxido polímero ; Coadyuvante medicamentoso ; Benzodiazepina derivado ; Hipnótico ; Psicotropo ; Tranquilizante ; Diazepam ; Temazepam ; Dispersión sólida ; Forma sólida ; Forma farmacéutica ;

Localisation / Location

INIST-CNRS, Cote INIST : 14753, 35400010309889.0050