Titre du document / Document title

A prospective evaluation of the interleukin-1 receptor antagonist intron 2 gene polymorphism and the risk of myocardial infarction

Auteur(s) / Author(s)

ZEE Robert Y. L. ^{(1 2 3)} ; LUNZE Karsten ⁽⁴⁾ ; LINDPAINTNER Klaus ⁽⁴⁾ ; RIDKER Paul M. ^{(1 2 3)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ETATS-UNIS
⁽²⁾ Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ETATS-UNIS
⁽³⁾ Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ETATS-UNIS
⁽⁴⁾ Division of Endocrine-Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ETATS-UNIS

Résumé / Abstract

While an interleukin-1 receptor antagonist gene polymorphism (ILIRN-VNTR) has recently been hypothesized to be a risk factor for coronary artery disease, no prospective data relating this polymorphism to subsequent risk of coronary events are available. We therefore investigated the association between ILIRN-VNTR genotype and the incidence of myocardial infarction (MI) in a large, prospective cohort of initially healthy men. The ILIRN-VNTR was evaluated among 385 Ml case subjects and an equal number of age- and smoking-matched control subjects during a 12-year follow-up. Overall, the allele and g enotype distributions were similar among cases and controls, both in the total cohort and in all subgroups evaluated. All observed genotype frequencies were in Hardy-Weinberg equilibrium. Furthermore, the relative risk in a comparison of homozygous mutant to homozygous wild-type was 0.89 (95%CI = 0.5-1.6; P = 0.9). In this large, prospective study, the ILIRN-VNTR gene polymorphism is not associated with risks of future MI. These data also highlight the importance of hypothesis testing studies in genetic epidemiology, particularly for hypotheses generated from small samples or post hoc subgroup analyses.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

2001, vol. 86, n^o5, pp. 1141-1143 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Genetics ; Myocardial disease ; Coronary heart disease ; Cardiovascular disease ; Interleukin 1 receptor antagonist ; Cohort study ; Human ; Male ; Mutation ; Polymorphism ; Gene ; Genotype ; Risk factor ; Myocardium ; Infarct ;

Mots-clés français / French Keywords

Génétique ; Myocarde pathologie ; Cardiopathie coronaire ; Appareil circulatoire pathologie ; Antagoniste récepteur interleukine 1 ; Etude cohorte ; Homme ; Mâle ; Mutation ; Polymorphisme ; Gène ; Génotype ; Facteur risque ; Myocarde ; Infarctus ;

Mots-clés espagnols / Spanish Keywords

Genética ; Miocardio patología ; Cardiopatía coronaria ; Aparato circulatorio patología ; Estudio cohorte ; Hombre ; Macho ; Mutación ; Polimorfismo ; Gen ; Genotipo ; Factor riesgo ; Miocardio ; Infarto ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400010291103.0030