Titre du document / Document title

The hematocrit-corrected erythrocyte sedimentation rate can be useful in diagnosing inflammation in hemodialysis patients

Auteur(s) / Author(s)

BORAWSKI Jacek ⁽¹⁾ ; MYSLIWIEC Michał ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Nephrology and Internal Medicine, Medical Academy, Białystok, POLOGNE

Résumé / Abstract

Background/Aims: We aimed to determine predictors of erythrocyte sedimentation rate (ESR), and the ESR level pointing to the presence of inflammation in 60 chronic hemodialysis (HD) patients. Methods/Results: On bivariate analysis, increased Westergren ESR of 62 (4-160) mm/h correlated inversely with hematocrit (Hct) and serum albumin, and positively with age, plasma fibrinogen, serum C-reactive protein (CRP), immunoglobulins A and G, α₁-acid-glycoprotein and α₁-antitrypsin. On multi-variable analysis, independent predictors of the ESR were raised CRP (p < 0.0001), low Hct (p < 0.0001), ), increased fibrinogen (p < 0.0001) and immunoglobulin A (p = 0.009), and older age (p = 0.015). The Hct-corrected ESR level [ESR × (Hct/45)] of 38 (4-91) mm/h was independently predicted by CRP (p < 0.0001), fibrinogen (p < 0.0001), and age (p = 0.001). In the patients with normal CRP and albumin, the Hct-corrected ESR value was normal (23 mm/h) and lower than that of 59 mm/h in the subjects with elevated CRP and hypoalbuminemia. Using these cut-off points, the positive and negative predictive values of the Hct-corrected ESR on the presence of inflammation were 1.0, and its sensitivity and specificity were 100%. Conclusion: Increased Westergren ESR in HD patients is associated with activated acute-phase response, anemia, and aging. The Hct-corrected ESR values of 23 and 59 mm/h precisely select the HD patients with severe inflammation from those without.

Revue / Journal Title

Nephron   ISSN 0028-2766   CODEN NPRNAY 

Source / Source

2001, vol. 89, n^o4, pp. 381-383 (10 ref.)

Langue / Language

Anglais

Editeur / Publisher

Karger, Basel, SUISSE  (1964-2002) (Revue)

Mots-clés anglais / English Keywords

Hemopathy ; Extrarenal dialysis ; Human ; Quantitative analysis ; Red blood cell ; Sedimentation ; Hematocrite ; Anemia ; Diagnosis ; Inflammation ; Hemodialysis ;

Mots-clés français / French Keywords

Hémopathie ; Epuration extrarénale ; Homme ; Analyse quantitative ; Erythrocyte ; Sédimentation ; Hématocrite ; Anémie ; Diagnostic ; Inflammation ; Hémodialyse ;

Mots-clés espagnols / Spanish Keywords

Hemopatía ; Depuración extrarrenal ; Hombre ; Análisis cuantitativo ; Eritrocito ; Sedimentación ; Hematocrito ; Anemia ; Diagnóstico ; Inflamación ; Hemodiálisis ;

Localisation / Location

INIST-CNRS, Cote INIST : 11890, 35400009934804.0040