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Titre du document / Document title

Pore diameter of more than 100 μm is not requisite for bone ingrowth in rabbits

Auteur(s) / Author(s)

ITÄLÄ Ari I. (1) ; YLÄNEN Heimo O. (2) ; EKHOLM Clifford (2) ; KARLSSON Kaj H. (2) ; ARO Hannu T. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Skeletal Research Program, Department of Surgery, University of Turku, Turku, FINLANDE
(2) Process Chemistry Group (Combustion and Materials Chemistry), Åbo Akademi University, Turku, FINLANDE

Résumé / Abstract

The optimal pore size for bone ingrowth is claimed to be 100-400 μm. With the use of a highly standardized experimental model, the present study reevaluated whether a pore size of 100 μm is the threshold value for bone ingrowth into porous structures under non-load-bearing conditions. Titanium triangle-shaped plates 250 or 500 μm thick were perforated with the use of a laser in order to create standard-sized holes (Ø 50, 75, 100, and 125 μm) in multiple rows. The amount of bone ingrowth through the implant holes was studied in the cancellous bone of the distal rabbit femur. Twelve weeks after implantation, detailed analysis of bone ingrowth was performed with computerized image analysis of backscattered electron imaging techniques of scanning electron microscopy. The results showed that the amount of ingrown new bone was independent of the pore size and implant thickness. The median value for bone ingrowth varied between 64 and 78%. A striking feature was the formation of secondary osteonal structures even in the smallest holes. Based on these results, there is no threshold value for new bone ingrowth in pore sizes ranging from 50 to 125 μm under non-load-bearing conditions.

Revue / Journal Title

Journal of biomedical materials research    ISSN  0021-9304   CODEN JBMRBG 

Source / Source

2001, vol. 58, no6, pp. 679-683 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1967-2002) (Revue)

Mots-clés anglais / English Keywords

Orthopedic surgery

;

Vertebrata

;

Mammalia

;

Lagomorpha

;

Biomedical engineering

;

Biomaterial

;

Diseases of the osteoarticular system

;

Experimental study

;

Bibliographic review

;

Bone

;

Incrustation

;

Rabbit

;

Scanning electron microscopy

;

Titanium alloy

;

Animal

;

Pore size

;

Pore structure

;

Mots-clés français / French Keywords

Chirurgie orthopédique

;

Vertebrata

;

Mammalia

;

Lagomorpha

;

Génie biomédical

;

Biomatériau

;

Système ostéoarticulaire pathologie

;

Etude expérimentale

;

Revue bibliographique

;

Os

;

Incrustation

;

Lapin

;

Microscopie électronique balayage

;

Titane alliage

;

Animal

;

Dimension pore

;

Structure pores

;

Mots-clés espagnols / Spanish Keywords

Cirugía ortopédica

;

Vertebrata

;

Mammalia

;

Lagomorpha

;

Ingeniería biomédica

;

Biomaterial

;

Sistema osteoarticular patología

;

Estudio experimental

;

Revista bibliográfica

;

Hueso

;

Incrustación

;

Conejo

;

Microscopía electrónica barrido

;

Titanio aleación

;

Animal

;

Dimensión poro

;

Estructura poros

;

Localisation / Location

INIST-CNRS, Cote INIST : 13764, 35400009422818.0110

Nº notice refdoc (ud4) : 14112364



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