Titre du document / Document title

In vitro release of metoclopramide from hydrophobic matrix tablets. influence of hydrodynamic conditions on kinetic release parameters

Auteur(s) / Author(s)

FRUTOS Paloma ⁽¹⁾ ; PABON Cristina ⁽¹⁾ ; LASTRES José L. ⁽¹⁾ ; FRUTOS Gloria ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmaceutical Technology, Complutense University, Madrid, ESPAGNE
⁽²⁾ Operational Research, Complutense University, Madrid, ESPAGNE

Résumé / Abstract

There has been growing interest in the subject of drug delivery and the design and evaluation of controlled-release systems. The simplest way to control the release of an active agent is to disperse it in an inert polymeric matrix. Controlled-release systems are of interest because they are technologically simple, relatively cheap, and practically unaffected by physiological changes. In this study, a new matrix system was formed by an active principle, metoclopramide hydrochloride, scattered into a biocompatible hydrophobic polymerical mesh, polyamide 12, to achieve sustained and controlled delivery of metoclopramide hydrochloride. This research was conducted to investigate the in vitro drug release behavior from these new inert polymeric matrix tablets. The drug release process was investigated both experimentally and by means of mathematical models. Different models were applied for the evaluation of drug release data. On the basis of our results, a biexponential equation was proposed, Q=Q¹_last(1-e^-Klastt)+Q²_slow(1-e^-Kslowt), in an attempt to explain the mechanism responsible for the release process. Additionally, the influence of the experimental conditions of the dissolution devices, such as rate of flow and pH of dissolution medium, on the parameters that characterize the release mechanism was studied, and it was found that the main factor was the hydrodynamic condition of rate of flow.

Revue / Journal Title

Chemical and pharmaceutical bulletin   ISSN 0009-2363   CODEN CPBTAL 

Source / Source

2001, vol. 49, n^o10, pp. 1267-1271 (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Maruzen, Tokyo, JAPON  (1958) (Revue)

Mots-clés anglais / English Keywords

Mathematical model ; Modeling ; Kinetics ; Flow rate ; pH ; Operating conditions ; Active ingredient ; In vitro ; Release ; Water solubility ; Dissolution ; Amide 12 polymer ; Control release polymer ; Benzamide derivatives ; Dopamine antagonist ; Antiemetic ; Metoclopramide ; Tablet ; Controlled release form ; Pharmaceutical technology ;

Mots-clés français / French Keywords

Modèle mathématique ; Modélisation ; Cinétique ; Débit ; pH ; Condition opératoire ; Principe actif ; In vitro ; Libération ; Hydrosolubilité ; Dissolution ; Amide 12 polymère ; Polymère vecteur ; Benzamide dérivé ; Antagoniste dopamine ; Antiémétique ; Métoclopramide ; Comprimé ; Forme libération contrôlée ; Technologie pharmaceutique ;

Mots-clés espagnols / Spanish Keywords

Modelo matemático ; Modelización ; Cinética ; Gasto ; pH ; Condición operatoria ; Principio activo ; In vitro ; Liberación ; Hidrosolubilidad ; Disolución ; Amida 12 polímero ; Polímero vector ; Benzamida derivado ; Antagonista dopamina ; Antiemético ; Metoclopramida ; Tableta ; Forma liberación controlada ; Tecnología farmacéutica ;

Localisation / Location

INIST-CNRS, Cote INIST : 4123, 35400009966731.0060