Titre du document / Document title
Urinary excretion of diazepam metabolites in healthy volunteers and drug users
Auteur(s) / Author(s)
SMITH-KIELLAND A.
(1) ;
SKUTERUD B.
(1) ;
OLSEN K. M.
(1) ;
MØRLAND J.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) National Institute of Forensic Toxicology, Oslo, NORVEGE
Résumé / Abstract
Urinary excretion profiles of diazepam metabolites were investigated. The subjects were healthy volunteers receiving one single 10-mg dose of diazepam or drug abusers starting a prison sentence. Urinary excretion of metabolites was analysed by immunological screening, liquid chromatography and gas chromatography-mass spectrometry. Relating the metabolite concentration to creatinine concentration in the specimens decreased sample-to-sample variations. In some cases such correction could protect a subject from erroneous accusations of a new intake.
Revue / Journal Title
Scandinavian journal of clinical & laboratory investigation
ISSN 0036-5513
CODEN SJCLAY
Source / Source
2001, vol. 61, n
o3, pp. 237-246 (13 ref.)
Langue / Language
Anglais
Editeur / Publisher
Scandinavian University Press, Oslo, NORVEGE
(1949)
(Revue)
Mots-clés anglais / English Keywords
Drug ;
Clinical biology ;
Benzodiazepine derivatives ;
Psychotropic ;
Healthy subject ;
Volunteer ;
Human ;
Excretion ;
Urine ;
Immunological method ;
Coupled method ;
Gas chromatography ;
Mass spectrometry ;
Liquid chromatography ;
Oxazepam ;
Metabolism ;
Quantitative analysis ;
Metabolite ;
Diazepam ;
Drug addiction ;
Mots-clés français / French Keywords
Médicament ;
Biologie clinique ;
Benzodiazépine dérivé ;
Psychotrope ;
Individu sain ;
Volontaire ;
Homme ;
Excrétion ;
Urine ;
Méthode immunologique ;
Méthode couplée ;
Chromatographie phase gazeuse ;
Spectrométrie masse ;
Chromatographie phase liquide ;
Oxazépam ;
Métabolisme ;
Analyse quantitative ;
Métabolite ;
Diazépam ;
Toxicomanie ;
Mots-clés espagnols / Spanish Keywords
Medicamento ;
Biología clínica ;
Benzodiazepina derivado ;
Psicotropo ;
Individuo sano ;
Voluntario ;
Hombre ;
Excreción ;
Orina ;
Método inmunológico ;
Método acoplado ;
Cromatografía fase gaseosa ;
Espectrometría masa ;
Cromatografía fase líquida ;
Oxazepam ;
Metabolismo ;
Análisis cuantitativo ;
Metabolito ;
Diazepam ;
Toxicomanía ;
Localisation / Location
INIST-CNRS, Cote INIST : 5797, 35400009825531.0070
Nº notice refdoc (ud4) : 14101392
