Titre du document / Document title

Vitamin B₁₂ cream containing avocado oil in the therapy of plaque psoriasis

Auteur(s) / Author(s)

STÜCKER Markus ⁽¹⁾ ; MEMMEL Ulrike ⁽¹⁾ ; HOFFMANN Matthias ⁽¹⁾ ; HARTUNG Joachim ⁽²⁾ ; ALTMEYER Peter ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Dermatology and Allergology, Ruhr University, Bochum, ALLEMAGNE
⁽²⁾ Department of Statistics of the University of Dortmund, ALLEMAGNE

Résumé / Abstract

Background: There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a rather significant risk of undesirable effects. Objective and Methods: In this randomized, prospective clinical trial, the effects of the vitamin D₃ analog calcipotriol were evaluated against those of a recently developed vitamin B₁₂ cream containing avocado oil in an intraindividual right/left-side comparison. The trial population consisted of 13 patients, 10 men and 3 women, with chronic plaque psoriasis. The observation period was 12 weeks; the effects of therapy were assessed on the basis of a PASI score adapted to the right/left-side comparison technique, the subjective evaluations of the investigator and patients and the results of 20-MHz sonography. Results: There was a a more rapid development of beneficial effects with the use of calcipotriol in the initial 8 weeks, although differences in effects were significant only at the time point of therapy week 8 (p < 0.05). After 12 weeks, neither the PASI score nor 20-MHz sonography showed significant differences between the two treatments. While the efficacy of the calcipotriol preparation reached a maximum in the first 4 weeks and then began to subside, the effects of the vitamin B₁₂ cream containing avocado oil remained at a constant level over the whole observation period. This would indicate that the vitamin B₁₂ preparation containing avocado oil may be suitable for use in long-term therapy, a hypothesis further supported by the fact that the investigator and the patients assessed the tolerability of the vitamin B₁₂ cream containing avocado oil as significantly better in comparison with that of calcipotriol. Conclusion: The results of this clinical trial provide evidence that the recently developed vitamin B₁₂ cream containing avocado oil has considerable potential as a well-tolerated, long-term topical therapy of psoriasis.

Revue / Journal Title

Dermatology    ISSN  1018-8665 

Source / Source

2001, vol. 203, n^o2, pp. 141-147 (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Karger, Basel, SUISSE  (1992) (Revue)

Mots-clés anglais / English Keywords

Skin disease ; B-Vitamins ; Antipsoriatic agent ; Human ; Plant origin ; Extract ; Treatment ; Avocado oil ; Psoriasis ; Percutaneous route ; Local administration ; Cyanocobalamin ;

Mots-clés français / French Keywords

Peau pathologie ; Vitamine B ; Antipsoriasique ; Homme ; Origine végétale ; Extrait ; Traitement ; Huile avocat ; Psoriasis ; Voie percutanée ; Voie locale ; Cyanocobalamine ;

Mots-clés espagnols / Spanish Keywords

Piel patología ; Vitamina B ; Antipsoriásico ; Hombre ; Origen vegetal ; Extracto ; Tratamiento ; Aceite aguacate ; Psoriasis ; Vía percutánea ; Vía local ; Cianocobalamina ;

Localisation / Location

INIST-CNRS, Cote INIST : 4530, 35400009923013.0070