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Titre du document / Document title

Cancer mortality among workers exposed to amphibole-free chrysotile asbestos

Auteur(s) / Author(s)

YANO Eiji (1) ; WANG Zhi-Ming (2) ; WANG Xiao-Rong (1 2 3) ; WANG Mian-Zheng (2) ; LAN Ya-Jia (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, JAPON
(2) Department of Occupational Medicine, West China University of Medical Sciences, Chengdu, CHINE
(3) Department of Environmental Health, Harvard School of Public Health, Boston, MA, ETATS-UNIS

Résumé / Abstract

The issue of whether exposure to chrysotile asbestos alone, without contamination from amphibole asbestos, causes lung cancer and mesothelioma was investigated in a 25-year longitudinal study (1972-1996) in Chongqin, China. The study cohort comprised 515 male asbestos plant workers exposed to chrysotile only; the control cohort included 650 non-dust-exposed workers. The results of analysis in which the proportional hazards model was used indicated that mortality due to all causes, all cancers, and lung cancer was related to asbestos exposure; the relative risks, adjusted for age and smoking, were 2.9, 4.3, and 6.6, respectively. Fiber concentrations in the raw material section and the textile section of the plant were 7.6 and 4.5 fibers/ml, respectively. Because of differences between the study and control plants, the authors also compared various sections of the asbestos plant that had different levels of dust exposure. The adjusted relative risk of lung cancer was 8.1 for workers exposed to high versus low levels of asbestos. Two cases of malignant mesothelioma, one pleural and the other peritoneal, were found in the asbestos cohort. These results suggest that heavy exposure to pure chrysotile asbestos alone, with negligible amphibole contamination, can cause lung cancer and malignant mesothelioma in exposed workers.

Revue / Journal Title

American journal of epidemiology    ISSN  0002-9262   CODEN AJEPAS 

Source / Source

2001, vol. 154, no6, pp. 538-543 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Cary, NC, ETATS-UNIS  (1965) (Revue)

Mots-clés anglais / English Keywords

Respiratory disease

;

Asia

;

Health and environment

;

Occupational medicine

;

Cohort study

;

China

;

Public health

;

Human

;

Risk factor

;

Epidemiology

;

Occupational exposure

;

Malignant mesothelioma

;

Asbestos

;

Lung

;

Malignant tumor

;

Mortality

;

Mots-clés français / French Keywords

Appareil respiratoire pathologie

;

Asie

;

Santé et environnement

;

Médecine travail

;

Etude cohorte

;

Chine

;

Santé publique

;

Homme

;

Facteur risque

;

Epidémiologie

;

Exposition professionnelle

;

Mésothéliome malin

;

Amiante

;

Poumon

;

Tumeur maligne

;

Mortalité

;

Mots-clés espagnols / Spanish Keywords

Aparato respiratorio patología

;

Asia

;

Salud y medio ambiente

;

Medicina ocupacional

;

Estudio cohorte

;

China

;

Salud pública

;

Hombre

;

Factor riesgo

;

Epidemiología

;

Exposición profesional

;

Mesotelioma maligno

;

Amianto

;

Pulmón

;

Tumor maligno

;

Mortalidad

;

Localisation / Location

INIST-CNRS, Cote INIST : 663, 35400009947970.0070

Nº notice refdoc (ud4) : 14073881



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