Titre du document / Document title

Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist

Auteur(s) / Author(s)

KOBAYASHI Yoshinori ⁽¹⁾ ; NAKANO Yumiko ⁽¹⁾ ; KIZAKI Miho ⁽¹⁾ ; HOSHIKUMA Kiyoko ⁽¹⁾ ; YOKOO Yoshiharu ⁽¹⁾ ; KAMIYA Toshikazu ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Kyowa Hakko Kogyo Co., Ltd. Tsukuba Research Laboratories, Ibaraki, JAPON

Résumé / Abstract

Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers to Evodia fruits as a hot nature herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodiamine has no perceptible taste, including a peppery hot taste. Therefore, the effectiveness of evodiamine and the extract of Evodia fruits in preventing obesity on male C3H mice, or male SD rats were examined. When evodiamine was supplemented at 0.03% of the diet and fed to mice for 12 days, the perirenal fat weight became significantly lower than in the control group. The epididymal fat mass was also decreased in the evodiamine diet group. When evodiamine was supplemented at 0.02 % in the form of ethanol extract of Evodia fruits to the high-fat diet and fed to rats for 21 days, the body weight, the perirenal fat weight, epididymal fat weight, the levels of serum free fatty acid, total lipids in the liver, triglyceride in the liver, and cholesterol level in the liver were significantly reduced as compared with the control diet group. Furthermore, both lipolytic activity in the perirenal fat tissue and specific GDP binding in brown adipose tissue mitochondria, as the biological index of enhanced heat production, were significantly increased in the evodiamine fed rats. Fasting mice subcutaneously administered 1-3 mg/kg evodiamine showed decreased core body temperature by 1 - 2 °C. This hypothermic effect was prevented by the pretreatment of intraperitoneally administered 10 mg/ kg capsazepine, a vanilloid receptor antagonist. On the other hand, food-sated mice subcutaneously administered 1-3 mg/kg evodiamine showed unchanged core body temperature and increased tail skin temperature by more than 5°C, suggesting the increased energy expenditure by enhanced heat dissipation. In conclusion, we have demonstrated that a novel non-pungent vanilloid receptor agonist, evodiamine, mimics the characteristic anti-obese effects induced by capsaicin. Evodiamine would induce heat loss and heat production at the same time and dissipate food energy, preventing the accumulation of perivisceral fat and the body weight increase.

Revue / Journal Title

Planta medica   ISSN 0032-0943   CODEN PLMEAA 

Source / Source

2001, vol. 67, n^o7, pp. 628-633 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1953) (Revue)

Mots-clés anglais / English Keywords

Nutrition disorder ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Rutaceae ; Plant origin ; Medicinal plant ; Nutritional status ; Pharmacognosy ; Rat ; Mouse ; Animal ; Male ; Prevention ; Phytotherapy ; Oriental medicine ; Folk medicine ; Vanilloid receptor ; Agonist ; Alkaloid ; Fruit ; Obesity ;

Mots-clés français / French Keywords

Trouble nutrition ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Rutaceae ; Evodiamine ; Evodia rutaecarpa ; Origine végétale ; Plante médicinale ; Etat nutritionnel ; Pharmacognosie ; Rat ; Souris ; Animal ; Mâle ; Prévention ; Phytothérapie ; Médecine orientale ; Médecine traditionnelle ; Récepteur vanilloïde ; Agoniste ; Alcaloïde ; Fruit ; Obésité ;

Mots-clés espagnols / Spanish Keywords

Trastorno nutricíon ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Rutaceae ; Origen vegetal ; Planta medicinal ; Estado nutricional ; Farmacognosia ; Rata ; Ratón ; Animal ; Macho ; Prevención ; Fitoterapia ; Medicina oriental ; Medicina tradicional ; Receptor vaniloide ; Agonista ; Alcaloide ; Fruto ; Obesidad ;

Localisation / Location

INIST-CNRS, Cote INIST : 9624, 35400009644122.0080