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Titre du document / Document title

The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent

Auteur(s) / Author(s)

THOMSON M. (1) ; AL-QATTAN K. K. (1) ; AL-SAWAN S. M. (1) ; ALNAQEEB M. A. (1) ; KHAN I. (2) ; ALI M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Biological Sciences, Faculty of Science, Safat, KOWEIT
(2) Department of Biochemistry, Faculty of Medicine, Kuwait University, KOWEIT

Résumé / Abstract

The effect of an aqueous extract of ginger (Zingiber oflicinale) on serum cholesterol and triglyceride levels as well as platelet thromboxane-B2 and prostaglandin-E2 production was examined. A raw aqueous extract of ginger was administered daily for a period of 4 weeks, either orally or intraperitoneally (IP) to rats. Fasting blood serum was investigated for thromboxane-B2, prostaglandin-E2, cholesterol and triglycerides. A low dose of ginger (50 mg/kg) administered either orally or IP did not produce any significant reduction in the serum thromboxane-B2 levels when compared to saline-treated animals. However, ginger administered orally caused significant changes in the serum PGE2 at this dose. High doses of ginger (500 mg/kg) were significantly effective in lowering serum PGE2 when given either orally or IP. However, TXB2 levels were significantly lower in rats given 500 mg/kg ginger orally but not IP. A significant reduction in serum cholesterol was observed when a higher dose of ginger (500 mg/kg) was administered. At a low dose of ginger (50 mg/kg), a significant reduction in the serum cholesterol was observed only when ginger was administered IP. No significant changes in serum triglyceride levels were observed upon administration of either the low or high dose of ginger. These results suggest that ginger could be used as an cholesterol-lowering, antithrombotic and anti-inflammatory agent.

Revue / Journal Title

Prostaglandins, leukotrienes and essential fatty acids    ISSN  0952-3278 

Source / Source

2002, vol. 67, no6, pp. 475-478 [4 page(s) (article)] (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1988) (Revue)

Mots-clés anglais / English Keywords

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Zingiberaceae

;

Asia

;

Zingiber officinale

;

Human

;

Pharmacognosy

;

China

;

Medicinal plant

;

Antiplatelet agent

;

Antiinflammatory agent

;

Flavoring crop

;

Plant origin

;

Biological activity

;

Mots-clés français / French Keywords

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Zingiberaceae

;

Asie

;

Zingiber officinale

;

Homme

;

Pharmacognosie

;

Chine

;

Plante médicinale

;

Inhibiteur thromboagrégation

;

Antiinflammatoire

;

Plante condimentaire

;

Origine végétale

;

Activité biologique

;

Mots-clés espagnols / Spanish Keywords

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Zingiberaceae

;

Asia

;

Zingiber officinale

;

Hombre

;

Farmacognosia

;

China

;

Planta medicinal

;

Inhibidor tromboagregación

;

Antiinflamatorio

;

Planta condimentaria

;

Origen vegetal

;

Actividad biológica

;

Localisation / Location

INIST-CNRS, Cote INIST : 18402, 35400010688167.0150

Nº notice refdoc (ud4) : 14043466



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