Titre du document / Document title

Effects of lorazepam and oxazepam on perceptual and procedural memory functions

Auteur(s) / Author(s)

MARTIN Janine ⁽¹⁾ ; MATTHEWS Allison ⁽¹⁾ ; MARTIN Frances ⁽¹⁾ ; KIRKBY Kenneth C. ⁽²⁾ ; ALEXANDER James ⁽¹⁾ ; DANIELS Brett ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ School of Psychology, University of Tasmania, GPO Box 252-30, Hobart, Tasmania 7001, AUSTRALIE
⁽²⁾ Discipline of Psychiatry, University of Tasmania, GPO Box 252-27, Hobart, Tasmania 7001, AUSTRALIE

Résumé / Abstract

Rationale: Lorazepam has been found to consistently impair performance on both episodic and perceptual priming tasks, whereas other benzodiazepines have shown perceptual priming to be preserved. However, it has recently been postulated that benzodiazepines may exert time-dependent effects on implicit memory processes after research findings indicated some benzodiazepines, other than lorazepam, impair performance on priming tasks when tested at the time of peak plasma concentration level after benzodiazepine administration. Objectives: To compare time-dependent effects of lorazepam and oxazepam on implicit memory tasks, specifically perceptual priming and procedural learning. Methods: Thirty-three healthy female undergraduates were randomised to one of three time groups (pre-peak, peak, post-peak) and administered placebo, 2.5 mg lorazepam, and 30 mg oxazepam, in counterbalanced order, at 1-week intervals. Assessments included word-stem completion (perceptual priming) and rotary pursuit (procedural learning) tasks. Results: At all time intervals, lorazepam but not oxazepam significantly impaired perceptual priming but procedural learning was preserved under both drugs. Conclusions: These findings are consistent with previous research showing a differential effect of lorazepam in impairing perceptual memory but the notion that benzodiazepines exert time-dependent effects on implicit memory processes was not supported.

Revue / Journal Title

Psychopharmacologia   ISSN 0033-3158   CODEN PSYPAG 

Source / Source

2002, vol. 164, n^o3, pp. 262-267 [6 page(s) (article)] (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1959) (Revue)

Mots-clés anglais / English Keywords

Oral administration ; Time response relation ; Acquisition process ; Benzodiazepine derivatives ; Procedural memory ; Priming ; Implicit memory ; Learning ; Memory ; Comparative study ; Healthy subject ; Female ; Human ; Biological activity ; Sedative ; Hypnotic ; Psychotropic ; Tranquillizer ; Oxazepam ; Lorazepam ;

Mots-clés français / French Keywords

Voie orale ; Relation temps réponse ; Processus acquisition ; Benzodiazépine dérivé ; Mémoire procédurale ; Primage ; Mémoire implicite ; Apprentissage ; Mémoire ; Etude comparative ; Individu sain ; Femelle ; Homme ; Activité biologique ; Sédatif ; Hypnotique ; Psychotrope ; Tranquillisant ; Oxazépam ; Lorazépam ;

Mots-clés espagnols / Spanish Keywords

Vía oral ; Relación tiempo respuesta ; Proceso adquisición ; Benzodiazepina derivado ; Memoria procedural ; Arrastre gotitas agua ; Memoria implícita ; Aprendizaje ; Memoria ; Estudio comparativo ; Individuo sano ; Hembra ; Hombre ; Actividad biológica ; Sedante ; Hipnótico ; Psicotropo ; Tranquilizante ; Oxazepam ; Lorazepam ;

Mots-clés d'auteur / Author Keywords

Lorazepam Oxazepam ; Benzodiazepines ; Implicit memory ; Priming ; Procedural memory ;

Localisation / Location

INIST-CNRS, Cote INIST : 1761, 35400010680081.0030