Titre du document / Document title

Effects of prednisone and ibuprofen on radio frequency volume tissue reduction in a rabbit model

Auteur(s) / Author(s)

HAN Joseph K. ⁽¹⁾ ; WOODSON B. Tucker ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, ETATS-UNIS

Résumé / Abstract

This study investigates whether acute anti-inflammatory medications (prednisone and ibuprofen) alter muscle volumetric reduction following radio frequency tissue ablation (RFTA). We used a rabbit model to measure changes in leg muscle volume using serial magnetic resonance imaging in 3 groups: RFTA without medication (group 1), RFTA with prednisone and ibuprofen (group 2), and no RFTA or medication (group 3). The mean volumetric changes for groups 1 and 2 differed on days I and 7 (+0.5 cm³ versus -0.4 cm³, p <.0001; and -0.03 cm³ versus -0.7 cm³, p <.05), but not on day 28 (-0.8 cm³ versus -1.0 cm³, not significant). Group 3 had no change in volume. The volumetric reduction varied. Impaired volumetric reduction (<50% mean change) occurred in 30% of extremities and correlated to lower tissue impedance (p <.04). Combined steroidal and nonsteroidal anti-inflammatory medications did decrease acute edema, but not the final volumetric reduction, following RFTA. Volumetric changes are variable and may be altered by tissue impedance.

Revue / Journal Title

The Annals of otology, rhinology & laryngology   ISSN 0003-4894   CODEN AORHA2 

Source / Source

Congrès
Meeting of the American Broncho-Esophagological Association, Palm Desert, California , ETATS-UNIS (14/05/2001)
2002, vol. 111, n^o11, pp. 968-971 [4 page(s) (article)] (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Annals Publishing Compagny, St. Louis, MO, ETATS-UNIS  (1897) (Revue)

Mots-clés anglais / English Keywords

Enzyme ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Immunosuppressive agent ; Antineoplastic agent ; Surgery ; ENT disease ; Vertebrata ; Mammalia ; Lagomorpha ; Arylpropionic acid derivatives ; Corticosteroid ; Rabbit ; Animal ; Chemotherapy ; Combined treatment ; Biological effect ; Experimental study ; Enzyme inhibitor ; Non steroidal antiinflammatory agent ; Ibuprofen ; Antiinflammatory agent ; Adrenal hormone ; Prednisolone ; Radiofrequency ; Tissue ; Volume ; Reduction ; Electrosurgery ; Sleep apnea syndrome ; Upper respiratory tract ; Obstruction ;

Mots-clés français / French Keywords

Enzyme ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Immunodépresseur ; Anticancéreux ; Chirurgie ; ORL pathologie ; Vertebrata ; Mammalia ; Lagomorpha ; Arylpropionique acide dérivé ; Corticostéroïde ; Lapin ; Animal ; Chimiothérapie ; Traitement associé ; Effet biologique ; Etude expérimentale ; Inhibiteur enzyme ; Antiinflammatoire non stéroïde ; Ibuprofène ; Antiinflammatoire ; Hormone surrénalienne ; Prednisolone ; Radiofréquence ; Tissu ; Volume ; Réduction ; Electrochirurgie ; Apnée sommeil syndrome ; Voie respiratoire supérieure ; Obstruction ;

Mots-clés espagnols / Spanish Keywords

Enzima ; Oxidoreductases ; Prostaglandin-endoperoxide synthase ; Inmunodepresor ; Anticanceroso ; Cirugía ; ORL patología ; Vertebrata ; Mammalia ; Lagomorpha ; Arilpropionico ácido derivado ; Corticoesteroide ; Conejo ; Animal ; Quimioterapia ; Tratamiento asociado ; Efecto biológico ; Estudio experimental ; Inhibidor enzima ; Antiinflamatorio no esteroide ; Ibuprofeno ; Antiinflamatorio ; Hormona suprarrenal ; Prednisolona ; Radiofrecuencia ; Tejido ; Volumen ; Reducción ; Electrocirugía ; Apnea sueno síndrome ; Vía respiratoria superior ; Obstrucción ;

Localisation / Location

INIST-CNRS, Cote INIST : 2077, 35400010545169.0030