Titre du document / Document title

Synovial cell sarcoma: Diagnosis, treatment, and outcomes

Auteur(s) / Author(s)

KARTHA Swapna S. ⁽¹⁾ ; BUMPOUS Jeffrey M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Otolaryngology, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, ETATS-UNIS

Résumé / Abstract

Objectives/Hypothesis: Synovial cell sarcoma is a mesenchymal tumor predominantly of the lower extremities. Three percent of cases arise in the head and neck region. It is thought that head and neck synovial sarcoma has a better prognosis than tumors of the extremities. Our experience has demonstrated aggressive behavior of this neoplasm in the head and neck. This compelled us to compare our experience with other studies. Study Design: Retrospective chart review. Methods: We obtained the records of patients diagnosed with head and neck synovial sarcoma from the Tumor Registry of the University of Louisville School of Medicine (Louisville, KY) and affiliated hospitals for data compiled between January 1990 and December 2000. Data on patient demographics, clinical findings and symptoms, histological findings, treatment, extent of disease, recurrence, and survival were recorded. The literature was reviewed identifying reports of synovial cell sarcoma. Results: Five consecutive patients with synovial cell sarcoma were assessed at our facility. The median patient age was 28.2 years. All of the patients underwent an aggressive primary surgical excision followed by irradiation. All patients received chemotherapy after recurrence. Four of the five patients had local recurrence, and all five of the patients developed distant metastases. Three of the patients have died, and two are alive with evidence of disease. Novel sites are reported including the ethmoid sinus and the parotid gland. This group demonstrated a 40% 5-year overall survival, which was lower than the 60% 5-year survival reported in the literature for all sites. Conclusions: Synovial cell sarcoma of the head and neck is a disease of young people and carries a poor prognosis. The aggressive nature of the disease may require modification of accepted treatment modalities and sequence.

Revue / Journal Title

The Laryngoscope   ISSN 0023-852X   CODEN LARYA8 

Source / Source

2002, vol. 112, n^o11, pp. 1979-1982 [4 page(s) (article)] (9 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Blackwell, Honboken, NJ., ETATS-UNIS  (1896) (Revue)

Mots-clés anglais / English Keywords

Medical imagery ; Radiodiagnosis ; Pathology ; ENT disease ; Malignant tumor ; Sarcoma ; Human ; Prognosis ; Treatment ; Diagnosis ; Retrospective ; Survival ; Radiotherapy ; Metastasis ; Computerized axial tomography ; Histopathology ; Head and neck ; Synovial sarcoma ;

Mots-clés français / French Keywords

Imagerie médicale ; Radiodiagnostic ; Anatomopathologie ; ORL pathologie ; Tumeur maligne ; Sarcome ; Homme ; Pronostic ; Traitement ; Diagnostic ; Rétrospective ; Survie ; Radiothérapie ; Métastase ; Tomodensitométrie ; Histopathologie ; Tête cou ; Synovialosarcome ;

Mots-clés espagnols / Spanish Keywords

Imaginería médica ; Radiodiagnóstico ; Anatomía patológica ; ORL patología ; Tumor maligno ; Sarcoma ; Hombre ; Pronóstico ; Tratamiento ; Diagnóstico ; Retrospectiva ; Sobrevivencia ; Radioterapia ; Metástasis ; Tomodensitometría ; Histopatología ; Cabeza cuello ; Sarcoma sinovial ;

Mots-clés d'auteur / Author Keywords

Synovial sarcoma ; head and neck neoplasm ; multimodality treatment ;

Localisation / Location

INIST-CNRS, Cote INIST : 3102, 35400010540053.0130