Titre du document / Document title

Evaluation of gentamicin-Eudragit microspheres as ophthalmic delivery systems in inflamed rabbit's eyes

Auteur(s) / Author(s)

SAFWAT S. M. ⁽¹⁾ ; AL-KASSAS R. S. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 17221, Riyadh 11484, ARABIE SAOUDITE

Résumé / Abstract

Gentamicin sulfate microspheres were prepared from poly methyl methacrylate (Eudragit RS and RL) polymers, cross-linked with polyvinyl alcohol, using a modified double emulsion-solvent evaporation technique. Successful trials were done to investigate the effectiveness of the prepared gentamicin-Eudragit microspheres in the treatment of inflamed rabbits' eyes. The healing effect of gentamicin-microspheres was compared with the marketed gentamicin eye drops and drug free particles. The healing rates of gentamicin formulations were treated as first-order kinetics from which the healing rate constants (k) and healing half-lives (t_1/2) were calculated. The results revealed that gentamicin-Eudragit microspheres have accelerated the rate of healing and reduced the healing half-life in comparison with the marketed gentamicin eye drops. Drug free particles gave comparable results with the control studies. The calculated healing half-lives for the gentamicin formulations were found to be 9 and 27 days for the microspheres and eye solution, respectively. The results of the statistical analysis assure the increase in therapeutic effectiveness and corneal retention of the developed ophthalmic drug delivery system.

Revue / Journal Title

STP pharma sciences   ISSN 1157-1489 

Source / Source

2002, vol. 12, n^o6, pp. 357-361 [5 page(s) (article)] (8 ref.)

Langue / Language

Anglais
Revue : Français

Editeur / Publisher

Editions de santé, Paris, FRANCE  (1991-2003) (Revue)

Mots-clés anglais / English Keywords

Vertebrata ; Mammalia ; Lagomorpha ; Biological activity ; Ophthalmic preparation ; Aminoglycoside ; Intraocular administration ; Encapsulation ; Delivery system ; Methacrylate polymer ; Comparative study ; Eye drop ; Animal ; Rabbit ; Eye disease ; Inflammation ; Microsphere ; Control release polymer ; Drug carrier ; Dosage form ; Pharmaceutical technology ; Antibacterial agent ; Antibiotic ; Gentamicin ;

Mots-clés français / French Keywords

Vertebrata ; Mammalia ; Lagomorpha ; Eudragit ; Activité biologique ; Forme ophtalmique ; Aminoglycoside ; Voie intraoculaire ; Encapsulation ; Système administration ; Méthacrylate polymère ; Etude comparative ; Collyre ; Animal ; Lapin ; Oeil pathologie ; Inflammation ; Microsphère ; Polymère vecteur ; Vecteur médicament ; Forme pharmaceutique ; Technologie pharmaceutique ; Antibactérien ; Antibiotique ; Gentamicine ;

Mots-clés espagnols / Spanish Keywords

Vertebrata ; Mammalia ; Lagomorpha ; Actividad biológica ; Forma oftálmica ; Aminoglicósido ; Vía intraocular ; Encapsulación ; Sistema administración ; Metacrilato polímero ; Estudio comparativo ; Colirio ; Animal ; Conejo ; Ojo patología ; Inflamación ; Microsfera ; Polímero vector ; Vector medicamento ; Forma farmacéutica ; Tecnología farmacéutica ; Antibacteriano ; Antibiótico ; Gentamicina ;

Localisation / Location

INIST-CNRS, Cote INIST : 20449 A, 35400010530849.0040