Titre du document / Document title

Comparison of high-dose finasteride (5 mg/day) versus low-dose finasteride (2.5 mg/day) in the treatment of hirsutism

Auteur(s) / Author(s)

BAYRAM Fahri ⁽¹⁾ ; MÜDERRIS I. Ipek ⁽²⁾ ; GÜVEN Muhammed ⁽¹⁾ ; KELESTIMUR Fahrettin ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Endocrinology and Metabolism, Faculty of Medicine, Erciges University, Kayseri, TURQUIE
⁽²⁾ Department of Obstetrics and Gynecology, Faculty of Medicine, Erciges University, Kayseri, TURQUIE

Résumé / Abstract

Objective: To compare the clinical efficacy and safety of high-dose (5 mg/day) and low-dose (2. 5 mg/ day) finasteride in the treatment of hirsutism in women. Design: A prospective, randomized and controlled clinical trial. Methods: Fifty-six hirsute women with moderate to severe hirsutism were prospectively evaluated to see the effects of low-dose (2.5 mg/day) and high-dose (5 mg/day) finasteride. Patients were randomly divided into two treatment groups. Group I (n = 29) received 2.5 mg finasteride/day and group II (n = 27) received 5 mg finasteride/day orally for 1 year. Hirsutism score, body mass index and hormonal parameters (FSH, LH, estradiol, androstenedione, testosterone, free testosterone, 17α-hydroxy-progesterone, dehydroepiandrosterone sulfate and sex hormone-binding globulin) were measured in all the patients before treatment and repeated at six-monthly intervals. Results: The hirsutism scores decreased significantly at months 6 and 12 from a mean±S.D. of 18.4± 4.6 to 13.3±5.2 (P < 0.001) and 18.4±4.6 to 8.6±4.2 (P < 0.001) in group I and from 18.7±5.2 to 13.9±5.3 (P < 0.001) and 18.7 ± 5.2 to 10.3 ± 5.0 (P < 0.001) in group II respectively. No significant changes in the blood chemistry and hormonal parameters except estradiol levels were observed. No serious side-effects were seen in the two groups. In group II, estradiol levels increased significantly at 6 and 12 months. Conclusions: In this study, hirsutism scores decreased significantly at 6 and 12 months in both groups I and II. Low-dose (2.5 mg/day) finasteride is safe and cost effective in the treatment of hirsutism and may be used instead of high-dose finasteride (5 mg/day) therapy.

Revue / Journal Title

European journal of endocrinology   ISSN 0804-4643 

Source / Source

2002, vol. 147, n^o4, pp. 467-471 [5 page(s) (article)] (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Portland Press, Colchester, ROYAUME-UNI  (1994) (Revue)

Mots-clés anglais / English Keywords

Skin disease ; Virilism ; Endocrinopathy ; Enzyme ; Oxidoreductases ; Azasteroid ; Hair ; Female ; Human ; Treatment efficiency ; Comparative study ; Treatment ; Low dose ; High dose ; Reductase ; Enzyme inhibitor ; Finasteride ; Hirsutism ;

Mots-clés français / French Keywords

Peau pathologie ; Virilisme ; Endocrinopathie ; Enzyme ; Oxidoreductases ; Azastéroïde ; Poil ; Femelle ; Homme ; Efficacité traitement ; Etude comparative ; Traitement ; Dose faible ; Dose forte ; Reductase ; Inhibiteur enzyme ; Finastéride ; Hirsutisme ;

Mots-clés espagnols / Spanish Keywords

Piel patología ; Virilismo ; Endocrinopatía ; Enzima ; Oxidoreductases ; Azasteroide ; Pelo ; Hembra ; Hombre ; Eficacia tratamiento ; Estudio comparativo ; Tratamiento ; Dosis débil ; Dosis fuerte ; Reductase ; Inhibidor enzima ; Finasterida ; Hirsutismo ;

Localisation / Location

INIST-CNRS, Cote INIST : 5321, 35400010655679.0050