Titre du document / Document title
High performance liquid chromatographic assay and drug dissolution studies of fluoxetine hydrochloride in capsule formulations
Auteur(s) / Author(s)
YILMAZ N.
(1 2) ;
ÖZKAN Y.
(1) ;
ÖZKAN S. A.
(2) ;
BIRYOL I.
(2) ;
ABOUL-ENEIN H. Y.
(3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Gülhane Military Medical Academy, Department of Pharmaceutical Technology, 06018, Etlik, Ankara, TURQUIE
(2) Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100, Ankara, TURQUIE
(3) Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, ARABIE SAOUDITE
Résumé / Abstract
A sensitive and simple high performance liquid chromatographic method for the assay of fluoxetine HCl was developed. The procedure is based on the use of the reversed-phase high performance liquid chromatographic method with UV detector. Each analysis required no longer than 6 minutes. The detector response was linear in the range of 0.01-50 μg/mL for fluoxetine HCl. The detection limit was found to be 0.0057 μg/mL. There was no significant difference between interday and intraday studies for fluoxetine HCl determined for two different concentrations. This method was applied, without any interferences from the excipients, for the determination of the drug in capsules and in drug dissolution studies. This method can be useful in routine quality control analysis of fluoxetine HCl pharmaceutical dosage form.
Revue / Journal Title
Journal of liquid chromatography & related technologies
ISSN 1082-6076
CODEN JLCTFC
Source / Source
2000, vol. 23, n
o11, pp. 1699-1710 (28 ref.)
Langue / Language
Anglais
Editeur / Publisher
Taylor & Francis, Colchester, ROYAUME-UNI
(1996)
(Revue)
Mots-clés anglais / English Keywords
Chemical analysis ;
Quantitative analysis ;
Release ;
Active ingredient ;
Dissolution ;
Fluoxetine ;
Antidepressant agent ;
Psychotropic ;
Reuptake inhibitor ;
Serotonin ;
Aminoether ;
Formulation ;
Capsule ;
Dosage form ;
Acidic solution ;
Kinetics ;
In vitro ;
HPLC chromatography ;
Reversed phase chromatography ;
Ultraviolet detector ;
Quality control ;
Mots-clés français / French Keywords
Analyse chimique ;
Analyse quantitative ;
Libération ;
Principe actif ;
Dissolution ;
Fluoxétine ;
Antidépresseur ;
Psychotrope ;
Inhibiteur recapture ;
Sérotonine ;
Aminoéther ;
Formulation ;
Capsule ;
Forme pharmaceutique ;
Solution acide ;
Cinétique ;
In vitro ;
Chromatographie HPLC ;
Chromatographie phase inverse ;
Détecteur UV ;
Contrôle qualité ;
Mots-clés espagnols / Spanish Keywords
Análisis químico ;
Análisis cuantitativo ;
Liberación ;
Principio activo ;
Disolución ;
Fluoxetina ;
Antidepresor ;
Psicotropo ;
Inhibidor recaptura ;
Serotonina ;
Aminoeter ;
Formulación ;
Cápsula ;
Forma farmacéutica ;
Solución ácida ;
Cinética ;
In vitro ;
Cromatografía HPLC ;
Cromatografía fase inversa ;
Detector UV ;
Control calidad ;
Localisation / Location
INIST-CNRS, Cote INIST : 18068, 35400008259369.0080
Nº notice refdoc (ud4) : 1397271
