Titre du document / Document title

Clinical characteristics and predictors of severe ketoacidosis at onset of type 1 diabetes mellitus in children in a North Rhine-Westphalian region, Germany

Auteur(s) / Author(s)

ROSENBAUER J. ; ICKS A. ; GIANI G. ;

Résumé / Abstract

Diabetic ketoacidosis is the most serious complication at the onset of type 1 diabetes mellitus (DM). In Germany, population-based data on its occurrence at DM onset are not yet available. In a population-based study in aNorth Rhine-Westphalian region, Germany, during 1993-95, data on the clinical presentation at type 1 DM onset were obtained from hospital records for 262 patients under 15 years of age (81% of eligible patients). Information on social status was obtained from 148 families by a standardized questionnaire. The most frequently reported symptoms were polyuria (93.9%), fatigue (64.2%) and weight loss (59.4%). Mean duration of symptoms was 3.5 weeks. At diagnosis 18.3% of the children presented impaired consciousness and 3.5% coma. Mean glucose level was 25.1 mmol/l. Severe ketoacidosis (pH ≤7.2) was present in 16.0% of the children. Metabolic derangement was more severe in children under 5 years. Low social status was significantly associated with increased risk of severe ketoacidosis (OR = 3.54, 95% CI: 1.10-11.35). Frequency of ketoacidosis at DM onset needs to be reduced through increased public and medical awareness of the presenting characteristics of childhood DM.

Revue / Journal Title

Journal of pediatric endocrinology & metabolism   ISSN 0334-018X 

Source / Source

2002, vol. 15, n^o8, pp. 1137-1145 [9 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Freund, Tel Aviv, ISRAEL  (1985) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 20997, 35400010207729.0050