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Titre du document / Document title

HLA-I-Antigenexpression korreliert mit dem histologischen Zelltyp uvealer Melanome = HLA class I antigen expression correlates with histologic cell type in uveal melanomas

Auteur(s) / Author(s)

DITHMAR S. (1 2) ; CROWDER J. (2) ; JAGER M. J. (3) ; VIGNISWARAN N. (4) ; GROSSNIKLAUS H. E. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Universitäts-Augenklinik Heidelberg, ALLEMAGNE
(2) Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, ETATS-UNIS
(3) Department of Ophthalmology, Leiden, PAYS-BAS
(4) Department of Oral Pathology, University of Alabama at Birmingham, Birmingham, AL, ETATS-UNIS

Résumé / Abstract

Purpose. The prognosis of uveal melanoma is correlated with its histologic cell type. The epithelioid cell type is associated with a higher metastatic rate than the spindle cell type.The Human Leucocyte Antigen Class I (HLA-I) expression of the melanoma also correlates with the prognosis. In this study, we analyzed HLA-I antigen expression of uveal melanomas to determine whether a relationship exists between antigenic expression and melanoma cell type. Methods. Formalin-fixed, paraffin-embedded spindle cell type (n=11) and epithelioid cell type (n=11) uveal melanomas were immunostained with the HC10 antibody (1:80) for HLA-I antigen expression with appropriate positive and negative controls. Sections were assessed semiquantitatively according to the percentage of stained cells. Results. Among the spindle cell type melanomas, 2 out of 11 (18%) stained with HC10 antibodies.The staining intensity was less than 25% of the cells in these two melanomas. Among the epithelioid cell type melanomas, 9 outof 11 (82%) stained with HC10. The staining intensity was more than 25% of the cells in 5 of these 9 melanomas. Conclusions. It is unknown why spindle and epithelioid cell type uveal melanomas have different prognoses. Human uveal melanoma cell lines with low HLA-I expression are susceptible to NK cell-mediated lysis in vitro and in murine studies.The prognostically more favorable spindle cell type melanoma expresses less HLA-I than the epithelioid cell type melanoma.These results stress the role of NK cells in the rejection of uveal melanoma.

Revue / Journal Title

Der Ophthalmologe    ISSN  0941-293X 

Source / Source

2002, vol. 99, no8, pp. 624-628 (18 ref.)

Langue / Language

Allemand

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1992) (Revue)

Mots-clés anglais / English Keywords

Pathology

;

Uvea disease

;

Eye disease

;

Malignant tumor

;

Human

;

Natural killer cell

;

Class I histocompatibility antigen

;

Epithelioid cell

;

Histopathology

;

Eye

;

Uvea

;

Malignant melanoma

;

Mots-clés français / French Keywords

Anatomopathologie

;

Uvée pathologie

;

Oeil pathologie

;

Tumeur maligne

;

Homme

;

Cellule NK

;

Antigène histocompatibilité classe I

;

Cellule épithélioïde

;

Histopathologie

;

Oeil

;

Uvée

;

Mélanome malin

;

Mots-clés espagnols / Spanish Keywords

Anatomía patológica

;

Uvea patología

;

Ojo patología

;

Tumor maligno

;

Hombre

;

Célula NK

;

Antígeno histocompatibilidad clase I

;

Célula epitelioide

;

Histopatología

;

Ojo

;

Uvea

;

Melanoma maligno

;

Localisation / Location

INIST-CNRS, Cote INIST : 21210, 35400010648302.0060

Nº notice refdoc (ud4) : 13958783



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