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Titre du document / Document title

Histopathological, morphometric and stereological studies of ascorbic acid and magnesium ascorbyl phosphate in a skin care formulation

Auteur(s) / Author(s)

SILVA G. M. (1) ; MAIA CAMPOS P. M. B. G. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo., BRESIL

Résumé / Abstract

Ascorbic acid (vitamin C) has been widely used in cosmetics and dermatological formulations due to its inhibitory effect on melanogenesis by affecting collagen synthesis and scavenger properties. However, ascorbic acid (AA) is quickly oxidized and decomposes in aqueous solution and to solve this problem, vitamin C derivatives were synthesized. In the present investigation, histopathological, morphometric and stereological studies were carried out to investigate the possible alterations caused by formulations containing AA or magnesium ascorbyl phosphate (MAP) in the epidermis. Gel creams either with or without 2% AA or its derivative were selected for investigation. Guinea-pigs were shaved on the back, and four areas of 1.5 cm2 each were used for the experiments. One untreated area was used for control and the others for the application of gel cream formulations either with or without AA or its derivatives. The formulations were applied daily for 2, 4 and 8 weeks and biopsies were then obtained from each area using a dermatological punch. The material collected was analysed by histopathological, morphometric and stereological techniques. We observed that, under the present experimental conditions, whole formulations acted on the epidermis causing a thickening of the epithelium, with cells of larger volume in the granulose and spinous layers.

Revue / Journal Title

International journal of cosmetic science    ISSN  0142-5463   CODEN IJCMDW 

Source / Source

2000, vol. 22, no3, pp. 169-179 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Malden, MA, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Biological activity

;

Skin

;

Epidermis

;

Hydration

;

Cosmetic

;

Ascorbic acid

;

Vitamin

;

Magnesium Compounds

;

Organic phosphate

;

Animal

;

Guinea pig

;

Histopathology

;

Morphometry

;

Stereology

;

Dermatology

;

Colloidal gel

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés français / French Keywords

Activité biologique

;

Peau

;

Epiderme

;

Hydratation

;

Cosmétique

;

Acide ascorbique

;

Vitamine

;

Magnésium Composé

;

Phosphate organique

;

Animal

;

Cobaye

;

Histopathologie

;

Morphométrie

;

Stéréologie

;

Dermatologie

;

Gel colloïdal

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés espagnols / Spanish Keywords

Actividad biológica

;

Piel

;

Epidermis

;

Hidratación

;

Cosmético

;

Acido ascórbico

;

Vitamina

;

Magnesio Compuesto

;

Fosfato orgánico

;

Animal

;

Cobayo

;

Histopatología

;

Morfometría

;

Estereología

;

Dermatología

;

Gel coloidal

;

Rodentia

;

Mammalia

;

Vertebrata

;

Localisation / Location

INIST-CNRS, Cote INIST : 19046, 35400008896160.0010

Nº notice refdoc (ud4) : 1394608



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