Titre du document / Document title

Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: A 3-year follow-up study

Auteur(s) / Author(s)

PASANTES-MORALES Herminia ⁽¹⁾ ; QUIROZ Hugo ⁽²⁾ ; QUESADA Octavio ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institute of Cell Physiology, National University of Mexico, Mexico City, MEXIQUE
⁽²⁾ Hospital of the Association to Prevent Blindness in Mexico, Mexico City, MEXIQUE

Résumé / Abstract

The purpose of this study to assess the effect of the formula taurine/diltiazem/vitamin E on the progression of visual field loss in retinitis pigmentosa. A double blind, placebo controlled study in 62 patients: visual field threshold values were obtained in a Humphrey Field Analyzer from center (30°) and periphery (30-60°), every 4 months during 3-year follow-up. Data were analyzed by univariate regression, with slopes obtained from the best fit lines. Based on slope values, three groups of patients were identified as those showing negative, positive, or zero slope: ≥ -1 to ≤ +1. In controls (32 patients), at central area, the distribution in negative, zero, or positive slope was, respectively, 16 (50%), 11 (35%), and 5 (15%). In the treated group (30 patients) this distribution was 6 (20%) negative, 17 (53%) zero, and 7 (23 %) positive slope. In periphery, 16 control patients were distributed as 11 (69%) negative, 4 (25%) zero, and 1 (6%) positive slope. In the treated group (17 patients), the distribution was opposite: 1 (6%) negative, 7 (41%) zero, and 9 (53%) positive slope. Nineteen patients receiving treatment up to 6 years showed similar distribution by slope values. Eight out of 9 patients switched from placebo (2 years) to treatment (2-3 years), showed improving changes in their slope values. A beneficial effect of the treatment decreasing the rate of visual field loss was observed, likely through a protective action from free radical reactions in affected photoreceptors.

Revue / Journal Title

Metabolic brain disease   ISSN 0885-7490   CODEN MBDIEE 

Source / Source

2002, vol. 17, n^o3, pp. 183-197 (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Springer, New York, NY, ETATS-UNIS  (1986) (Revue)

Mots-clés anglais / English Keywords

Genetic disease ; Retinopathy ; Eye disease ; Benzothiazepine derivatives ; Aminoacid ; Chemotherapy ; Human ; Combined treatment ; Follow up study ; E-Vitamins ; Diltiazem ; Taurine ; Visual field disease ; Retinitis pigmentosa ;

Mots-clés français / French Keywords

Maladie héréditaire ; Rétinopathie ; Oeil pathologie ; Benzothiazépine dérivé ; Aminoacide ; Chimiothérapie ; Homme ; Traitement associé ; Etude longitudinale ; Vitamine E ; Diltiazem ; Taurine ; Champ visuel pathologie ; Rétinite pigmentaire ;

Mots-clés espagnols / Spanish Keywords

Enfermedad hereditaria ; Retinopatía ; Ojo patología ; Benzotiazepina derivado ; Aminoácido ; Quimioterapia ; Hombre ; Tratamiento asociado ; Estudio longitudinal ; Vitamina E ; Diltiazem ; Taurina ; Campo visual patología ; Retinitis pigmentaria ;

Localisation / Location

INIST-CNRS, Cote INIST : 20951, 35400010929538.0070