Titre du document / Document title

Pleomorphic adenocarcinoma of the ciliary epithelium: a clinicopathological, immunohistochemical, ultrastructural, DNA-ploidy and comparative genomic hybridization analysis of an unusual case

Auteur(s) / Author(s)

NICOLO M. ⁽¹⁾ ; NICOLO G. ⁽²⁾ ; ZINGIRIAN M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Ophthalmology Section of the Department of Neurological and Visual Sciences, University of Genova, ITALIE
⁽²⁾ National Cancer Research Institute, Genova, ITALIE

Résumé / Abstract

PURPOSE. To describe detailed phenotypic and genotypic analysis of a pleomorphic adenocarcinoma of the ciliary epithelium (CE). CASE REPORT. An 86-year-old white woman developed an enlarging mass protruding from her previously eviscerated left eye 2 months postoperatively. Based on light and ultrastructural microscopy, the final diagnosis was a pleomorphic adenocarcinoma of the ciliary epithelium (CE). DISCUSSION. Cell proliferation indices confirmed the unusually rapid growth rate of this tumor; the peridiploid DNA content might explain the relatively low incidence of distant metastases. An imbalance o the chromosome 6 was also found by Comparative Genomic Hybridization (CGH).

Revue / Journal Title

European Journal of Ophthalmology   ISSN 1120-6721 

Source / Source

2002, vol. 12, n^o4, pp. 319-323 (9 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wichtig, Milano, ITALIE  (1991) (Revue)

Mots-clés anglais / English Keywords

Pathology ; Uvea disease ; Eye disease ; Malignant tumor ; Human ; Exploration ; Case study ; Comparative genomic hybridization ; Ploidy ; DNA ; Ultrastructure ; Immunohistochemistry ; Ciliary body ; Adenocarcinoma ;

Mots-clés français / French Keywords

Anatomopathologie ; Uvée pathologie ; Oeil pathologie ; Tumeur maligne ; Homme ; Exploration ; Etude cas ; Hybridation génomique comparative ; Ploïdie ; DNA ; Ultrastructure ; Immunohistochimie ; Corps ciliaire ; Adénocarcinome ;

Mots-clés espagnols / Spanish Keywords

Anatomía patológica ; Uvea patología ; Ojo patología ; Tumor maligno ; Hombre ; Exploración ; Estudio caso ; Hibridación genómica comparativa ; Ploidía ; DNA ; Ultraestructura ; Inmunohistoquímica ; Cuerpo ciliar ; Adenocarcinoma ;

Localisation / Location

INIST-CNRS, Cote INIST : 22516, 35400010925346.0120