Titre du document / Document title

Randomised trial of the effect of orlistat on body weight and cardiovascular disease risk profile in obese patients: UK multimorbidity study

Auteur(s) / Author(s)

UK Multimorbidity Study Group, ROYAUME-UNI
BROOM I. ⁽¹⁾ ; WILDING J. ⁽²⁾ ; STOTT P. ⁽³⁾ ; MYERS N. ⁽⁴⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Clinical Biochemistry, University of Aberdeen and Grampian University Hospitals Trust, Aberdeen, ETATS-UNIS
⁽²⁾ Department of Medicine, Diabetes and Endocrinology, University Hospital Aintree, Liverpool, ETATS-UNIS
⁽³⁾ The Surgery, Tadworth, Surrey, ETATS-UNIS
⁽⁴⁾ Brookroyd House, Heckmondike, West Yorkshire, ROYAUME-UNI

Résumé / Abstract

The potential effect of orlistat on cardiovascular co-morbidities may have been previously underestimated. This study assesses the efficacy of orlistat therapy for weight loss and cardiovascular risk factor reduction in obese patients with cardiovascular risk. This was a 54-week, double-blind, randomised, placebo-controlled, parallel group study with 531 patients being randomised. Mean weight loss was significantly greater with orlistat than with placebo (5.8% vs 2.3%; p<0.0001). Orlistat was also associated with significantly greater improvements than placebo in diastolic BP (-5.5 vs -3.1 mmHg; p<0.01), systolic blood pressure (-6.0 vs -2.3 mmHg; p<0.01), oral glucose tolerance test (-0.37 vs +0.09 mmol/l; p<0.05), fasting glucose (-0.19 vs +0.06 mmol/l; p<0.05), total cholesterol (-1.31% vs +3.78%; p<0.0001), LDL-cholesterol (-7.09% vs -0.55%; p<0.0001) and waist circumference (-5.99 vs -2.60 cm; p<0.0001). Orlistat was well tolerated. Orlistat weight loss is associated with improvements in cardiovascular co-morbidities, and hence cardiovascular risk.

Revue / Journal Title

International journal of clinical practice   ISSN 1368-5031 

Source / Source

2002, vol. 56, n^o7, pp. 494-499 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1997) (Revue)

Mots-clés anglais / English Keywords

Corporal biometry ; Nutrition disorder ; Nutritional status ; Human ; Treatment efficiency ; Treatment ; Chemotherapy ; Controlled therapeutic trial ; Orlistat ; Body weight ; Weight loss ; Risk factor ; Cardiovascular disease ; Obesity ;

Mots-clés français / French Keywords

Biométrie corporelle ; Trouble nutrition ; Etat nutritionnel ; Homme ; Efficacité traitement ; Traitement ; Chimiothérapie ; Essai thérapeutique contrôlé ; Orlistat ; Poids corporel ; Perte poids ; Facteur risque ; Appareil circulatoire pathologie ; Obésité ;

Mots-clés espagnols / Spanish Keywords

Biometría corporal ; Trastorno nutricíon ; Estado nutricional ; Hombre ; Eficacia tratamiento ; Tratamiento ; Quimioterapia ; Ensayo terapéutico controlado ; Orlistat ; Peso corporal ; Adelgazamiento ; Factor riesgo ; Aparato circulatorio patología ; Obesidad ;

Localisation / Location

INIST-CNRS, Cote INIST : 15561, 35400010472208.0020