Titre du document / Document title

Sertraline pharmacokinetics and dynamics in adolescents

Auteur(s) / Author(s)

AXELSON David A. ⁽¹⁾ ; PEREL James M. ⁽¹⁾ ; BIRMAHER Boris ⁽¹⁾ ; RUDOLPH George R. ⁽¹⁾ ; NUSS Sharon ⁽¹⁾ ; BRIDGE Jeffrey ⁽¹⁾ ; BRENT David A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, ETATS-UNIS

Résumé / Abstract

Objective: To determine the pharmacokinetics of sertraline in adolescents and assess its effect on a surrogate marker of serotonin transport. Method: Pharmacokinetic parameters of a single 50-mg dose of sertraline were determined in 10 adolescents. Steady-state withdrawal kinetics were determined in 12 adolescents taking 50 mg/day and in 6 adolescents taking 100 to 150 mg/day. Platelet serotonin reuptake was measured before and after 2 weeks of daily 50-mg dosing. Results: The mean steady-state half-life of 50 mg was significantly shorter (15.3 ± 3.5 hours) than the single-dose half-life (26.7 ± 5.2 hours; t = 6.4, p <.001) and the steady-state half-life at 100 to 150 mg/day (20.4 ± 3.4 hours; t = 2.9, p =.01). Platelet serotonin reuptake was inhibited by 61 ± 15% after approximately 2 weeks of sertraline 50 mg/day. Conclusions: The half-life of sertraline 50 mg becomes significantly shorter from the initial dose to steady-state, and many adolescents may benefit from twice-per-day dosing. The steady-state half-life increases as the dose increases. The moderate levels of platelet reuptake inhibition at 50 mg/day indicate that most adolescents may need sertraline doses higher than 50 mg/day to attain a therapeutic response.

Revue / Journal Title

Journal of the American Academy of Child and Adolescent Psychiatry   ISSN 0890-8567   CODEN JAAPEE 

Source / Source

2002, vol. 41, n^o9, pp. 1037-1044 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott, Hagerstown, MD, ETATS-UNIS  (1987) (Revue)

Mots-clés anglais / English Keywords

Human ; Adolescent ; Platelet ; Serotonin ; Reuptake inhibitor ; Psychotropic ; Antidepressant agent ; Pharmacokinetics ; Sertraline ;

Mots-clés français / French Keywords

Homme ; Naphthylamine dérivé ; Adolescent ; Thrombocyte ; Sérotonine ; Inhibiteur recapture ; Psychotrope ; Antidépresseur ; Pharmacocinétique ; Sertraline ;

Mots-clés espagnols / Spanish Keywords

Hombre ; Adolescente ; Trombocito ; Serotonina ; Inhibidor recaptura ; Psicotropo ; Antidepresor ; Farmacocinética ; Sertralina ;

Localisation / Location

INIST-CNRS, Cote INIST : 2261, 35400010915248.0030