Titre du document / Document title

Virus papiloma humano en mujeres quechuas jujenas con alta frecuencia de cancer de cuello uterino. Tipos virales y variantes de HPV16 = Human papilloma virus in Quechua women from Jujuy with high frequency of cervical carcinoma. Viral types and HPV-16 variants

Auteur(s) / Author(s)

PICCONI Maria Alejandra ; GRONDA Jorge ; ALONIO Lidia V. ; VILLA Luisa L. ; SICHERO Laura ; MIRANDA Sergio ; BARCENA Martin ; TEYSSIE Angelica ;

Résumé / Abstract

Viral types and HPV-16 variants. Human Papillomaviruses (HPVs) are etiologically associated to cervical carcinoma. In order to evaluate HPV infection and its relationship with the high frequency of this neoplasia in Quechua women from Jujuy (Argentina), 271 cervical samples from preneoplastic and neoplastic lesions (biopsies) and normal controls (cytologies) were studied. Detection and typing were performed using PCR-RFLP or PCR-hybridization and the HPV-16 variability in L1 and E6 genes (by PCR-hybridization) was analysed. HPV was detected in 52% of controls, 91% of low-grade lesions, 97% of high-grade lesions and 100% of invasive carcinomas, corresponding 55% to HPV-16. HPV-16 European variants were predominant, most of them being non-prototypic strains. The high frequency of high risk infection types and the raised proportion of HPV-16 non-prototypic variants related to a greater oncogenic potential could explain, in part, the high cervical cancer frequency of this native population. These data may contribute to disease control and vaccinal formulation.

Revue / Journal Title

Medicina    ISSN  0025-7680   CODEN MEDCAD 

Source / Source

2002, vol. 62, n^o3, pp. 209-220 [12 page(s) (article)]

Langue / Language

Espagnol

Editeur / Publisher

Fundación Revista Medicina, Buenos Aires, ARGENTINE  (1940) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 10720, 35400010902238.0010