Titre du document / Document title

Real-time MR image acquisition during high-dose dobutamine hydrochloride stress for detecting left ventricular wall-motion abnormalities in patients with coronary arterial disease

Auteur(s) / Author(s)

SCHALLA Simon ⁽¹⁾ ; KLEIN Christoph ⁽¹⁾ ; PAETSCH Ingo ⁽¹⁾ ; LEHMKUHL Hans ⁽¹⁾ ; BORNSTEDT Axel ⁽¹⁾ ; SCHNACKENBURG Bernhard ⁽²⁾ ; FLECK Eckart ⁽¹⁾ ; NAGEL Eike ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Internal Medicine-Cardiology, German Heart institute Berlin, Augustenburger Platz I, 13353 Berlin, ALLEMAGNE
⁽²⁾ Philips Medical Systems, Hamburg, ALLEMAGNE

Résumé / Abstract

PURPOSE: To compare the accuracy of real-time magnetic resonance (MR) imaging with that of standard echo-planar MR imaging for detecting myocardial wall-motion abnormalities at rest and during dobutamine hydrochloride-induced stress in patients with coronary arterial disease. MATERIALS AND METHODS: In 22 patients with coronary arterial disease, left ventricular wall motion was examined at rest and during dobutamine hydrochloride stress, by using echo-planar MR imaging and a new technique with real-time segmented k-space turbo gradient-echo echo-planar MR imaging (repetition time, 16.5 msec; echo time, 6.8 msec). Wall-motion abnormalities were determined visually for each perfusion territory, and Cohen K coefficients were calculated for real-time imaging in comparison with echo-planar imaging. Coronary angiography was performed in all patients. Sensitivity and specificity for real-time and echo-planar imaging were calculated for detecting significant coronary arterial stenosis. RESULTS: K values for detecting wall-motion abnormalities at real-time imaging, in comparison with echo-planar MR imaging, were 0.97 at rest and 0.94 at maximum dobutamine hydrochloride stress. At comparison with those of angiography, the sensitivity and specificity for detecting significant coronary arterial stenosis were 88% (14 of 16 patients) and 83% (five of six patients), respectively, for echo-planar imaging and 81% (13 of 16 patients) and 83% (five of six patients), respectively, for real-time imaging. CONCLUSION: Real-time MR imaging is possible under stress conditions and allows accurate detection of wall-motion abnormalities.

Revue / Journal Title

Radiology   ISSN 0033-8419   CODEN RADLAX 

Source / Source

2002, vol. 224, n^o3, pp. 845-851 (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

Radiological Society of North America, Oak Brook, IL, ETATS-UNIS  (1923) (Revue)

Mots-clés anglais / English Keywords

Cardiotonic agent ; Medical imagery ; Cardiovascular disease ; Image analysis ; Comparative study ; Human ; Diagnosis ; Accuracy ; Technique ; Motion ; Wall ; Left ventricle ; Stress ; High dose ; Chemotherapy ; Image ; Dobutamine ; Acquisition ; Real time ; Nuclear magnetic resonance imaging ; Plane ; Echo ; Coronary heart disease ;

Mots-clés français / French Keywords

Cardiotonique ; Imagerie médicale ; Appareil circulatoire pathologie ; Analyse image ; Etude comparative ; Homme ; Diagnostic ; Précision ; Technique ; Mouvement ; Paroi ; Ventricule gauche ; Stress ; Dose forte ; Chimiothérapie ; Image ; Dobutamine ; Acquisition ; Temps réel ; Imagerie RMN ; Plan ; Echo ; Cardiopathie coronaire ;

Mots-clés espagnols / Spanish Keywords

Cardiotónico ; Imaginería médica ; Aparato circulatorio patología ; Análisis imagen ; Estudio comparativo ; Hombre ; Diagnóstico ; Precisión ; Técnica ; Movimiento ; Pared ; Ventrículo izquierdo ; Estrés ; Dosis fuerte ; Quimioterapia ; Imagen ; Dobutamina ; Adquisición ; Tiempo real ; Imaginería RMN ; Plano ; Eco ; Cardiopatía coronaria ;

Localisation / Location

INIST-CNRS, Cote INIST : 6163, 35400010902329.0340