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Titre du document / Document title

Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele

Auteur(s) / Author(s)

AVRAMOPOULOS D. (1) ; STEFANIS N. C. (1) ; HANTOUMI I. (1) ; SMYRNIS N. (1 2) ; EVDOKIMIDIS I. (2) ; STEFANIS C. N. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) University Mental Health Research Institute, Argyrocastrou and Ionias St, Papagou, Athens 15669, GRECE
(2) Department of Neurology, National and Kapodestrian University of Athens, School of Medicine, Eginition Hospital, Vas Sofias 72, Athens 11528, GRECE

Résumé / Abstract

The gene for COMT is located on chromosome 22q11, an area that has been implicated in the pathogenesis of schizophrenia through linkage studies and through the detection of deletions in schizophrenics and velocardiofacial syndrome patients that often present psychotic symptomatology. Additionally catechol-O-methyl transferase activity has been found increased in schizophrenia and a functional polymorphism in the COMT gene itself has been associated with the disease, as well as with aggression in patients. We tested the hypothesis that COMT genotype for the functional Val158Met might contribute to the variance of self reported schizotypy and aggression scores in the normal population. We genotyped 379 healthy 18- to 24-year-old male individuals who had completed the PAS, SPQ and AQ questionnaires. Our results showed that self-reported schizotypy scores in both questionnaires were significantly related to COMT genotype (p = 0.028 for the PAS and p = 0.015 for the SPQ) with individuals homozygous for the high activity allele showing the highest scores. No significant differences were detected for AQ scores. We conclude that the COMT genotype for the functional Val158-Met polymorphism is correlated to self-reported schizotypy in healthy males. This finding is in the same direction as reported findings on schizophrenia and it adds to the list of evidence that COMT or a nearby gene in linkage disequilibrium is involved in the pathogenesis of the disease.

Revue / Journal Title

Molecular psychiatry    ISSN  1359-4184 

Source / Source

2002, vol. 7, no7, pp. 706-711 [6 page(s) (article)] (59 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing Group, Basingstoke, ROYAUME-UNI  (1996) (Revue)

Mots-clés anglais / English Keywords

Psychosis

;

Personality disorder

;

Enzyme

;

Transferases

;

Methyltransferases

;

Human

;

Etiopathogenesis

;

Schizotypal Personality Scale

;

Perceptual Aberration Magical Ideation Scale

;

Aggressiveness

;

Questionnaire

;

Allele

;

Chromosome

;

Genotype

;

Schizophrenia

;

Catechol O-methyltransferase

;

Exploration

;

Schizotypal personality

;

Mots-clés français / French Keywords

Psychose

;

Trouble personnalité

;

Enzyme

;

Transferases

;

Methyltransferases

;

Agression Questionnaire Buss-Perry

;

Homme

;

Etiopathogénie

;

Schizotypal Personality Scale

;

Perceptual Aberration Magical Ideation Scale

;

Agressivité

;

Questionnaire

;

Allèle

;

Chromosome

;

Génotype

;

Schizophrénie

;

Catechol O-methyltransferase

;

Exploration

;

Personnalité schizotypique

;

Mots-clés espagnols / Spanish Keywords

Psicosis

;

Trastorno personalidad

;

Enzima

;

Transferases

;

Methyltransferases

;

Hombre

;

Etiopatogenia

;

Schizotypal Personality Scale

;

Perceptual Aberration Magical Ideation Scale

;

Agresividad

;

Cuestionario

;

Alelo

;

Cromosoma

;

Genotipo

;

Esquizofrenia

;

Catechol O-methyltransferase

;

Exploración

;

Personalidad esquizotípica

;

Localisation / Location

INIST-CNRS, Cote INIST : 26439, 35400010197334.0050

Nº notice refdoc (ud4) : 13851192



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