Titre du document / Document title

Total antioxidant capacity is reduced in Crohn's disease

Auteur(s) / Author(s)

KOCH Timothy R. ⁽¹⁾ ; STRYKER Steven J. ⁽²⁾ ; TELFORD Gordon L. ⁽³⁾ ; OPARA Emmanuel C. ⁽⁴⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Section of Gastroenterology, LA Johnson VA Medical Center, West Virginia University, Morgantown, WV, ETATS-UNIS
⁽²⁾ Department of Surgery, Northwestern University Medical Center, Chicago, IL, ETATS-UNIS
⁽³⁾ Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, ETATS-UNIS
⁽⁴⁾ Department of Surgery, Duke University, Durham, NC, ETATS-UNIS

Résumé / Abstract

In previous work we identified depletion of the micronutrient glutathione in colon from patients with Crohn's disease. Since there are several linked intestinal antioxidant systems, we hypothesized that there would be global alteration of the tissue content of antioxidants in Crohn's disease. We therefore examined total antioxidant capacity and lipid hydroperoxide levels in colon from non-obstructed neoplasia and acquired megacolon as non-inflammatory controls and in colon from Crohn's disease. Total antioxidant capacity in the mucosal-submucosal layer was decreased in Crohn's disease (pANOVA = .02) and there was a strong trend toward decreased total antioxidant capacity in the muscularis externa layer from Crohn's disease (p = .06). There were trends toward increased lipid hydroperoxide levels in Crohn's disease. This study supports the presence of a generalized consumption of tissue antioxidants in Crohn's disease. The clinical response to nutritional therapy in patients with Crohn's disease may be related to repletion of tissue antioxidants.

Revue / Journal Title

Nutrition research   ISSN 0271-5317   CODEN NTRSDC 

Source / Source

2002, vol. 22, n^o7, pp. 825-833 (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1981) (Revue)

Mots-clés anglais / English Keywords

Inflammatory disease ; Intestinal disease ; Digestive diseases ; Digestive system ; Gut ; Human ; Pathophysiology ; Crohn disease ; Lipids ; Peroxidation ; Colon ; Antioxidant ; Biological activity ; Micronutrient ; Glutathione ;

Mots-clés français / French Keywords

Maladie inflammatoire ; Intestin pathologie ; Appareil digestif pathologie ; Appareil digestif ; Intestin ; Homme ; Physiopathologie ; Entérite Crohn ; Lipide ; Peroxydation ; Côlon ; Antioxydant ; Activité biologique ; Micronutriment ; Glutathion ;

Mots-clés espagnols / Spanish Keywords

Enfermedad inflamatoria ; Intestino patología ; Aparato digestivo patología ; Aparato digestivo ; Intestino ; Hombre ; Fisiopatología ; Enteritis Crohn ; Lípido ; Peroxidación ; Colón ; Antioxidante ; Actividad biológica ; Micronutriente ; Glutatión ;

Localisation / Location

INIST-CNRS, Cote INIST : 18812, 35400010827310.0060