Titre du document / Document title

Effect of prophylactic brimonidine on bleeding complications and flap adherence after laser in situ keratomileusis

Auteur(s) / Author(s)

NORDEN Richard A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Norden Laser Eye Associates, Ridgewood, NJ, ETATS-UNIS

Résumé / Abstract

PURPOSE: Several authors have assessed the effect of prophylactic briomonidine on bleeding complications and flap adherence after laser in situ keratomileusis (LASIK). This study further evaluates these potential associations. METHODS: We performed a prospective, double-masked, single-surgeon study of 31 patients (61 eyes) who underwent LASIK with or without prophylactic brimonidine for primary myopia/ myopic astigmatism (59 eyes) or hyperopic astigmatism (2 eyes). Among myopes, mean preoperative sphere was -4.44 ± 2.21 D and mean cylinder was -1.04 ± 1.01 D. Thirty-three eyes (54%) had nasal hinges; 28 eyes (46%) had superior hinges. RESULTS: Subconjunctival hemorrhage was observed in 22 of 61 eyes (36.1%). Three of these 22 eyes (13.6%) received prophylactic brimonidine; the remaining 19 eyes with subconjunctival hemorrhage (86.3%) did not receive brimonidine (P<.0001). All but three eyes had some hyperemia; however, the amount of hyperemia was lower in the brimonidine group (P<.0001). Bleeding from the superior micropannus occurred in four of 61 eyes (6.6%). One of these four eyes received brimonidine. There was one case of flap slippage in a non-brimonidine eye with a nasal hinge; no flap striae were observed after repositioning. CONCLUSION: This study suggests that brimonidine administered before LASIK may significantly reduce subconjunctival hemorrhage and reduce the amount of hyperemia.

Revue / Journal Title

Journal of refractive surgery   ISSN 1081-597X   CODEN JRSUFZ 

Source / Source

2002, vol. 18, n^o4, pp. 468-471 (5 ref.)

Langue / Language

Anglais

Editeur / Publisher

Slack, Thorofare, NJ, ETATS-UNIS  (1995) (Revue)

Mots-clés anglais / English Keywords

Quinoxaline derivatives ; Imidazole derivatives ; Human ; Postoperative ; Keratomileusis ; In situ ; Laser ; Cornea ; Complication ; Antiglaucomatous agent ; α2-Adrenergic receptor ; Agonist ; Brimonidine ; Flap (surgery) ; Adhesion ; Hemorrhage ; Prevention ; Chemoprophylaxis ;

Mots-clés français / French Keywords

Quinoxaline dérivé ; Imidazole dérivé ; Homme ; Postopératoire ; Kératomileusis ; In situ ; Laser ; Cornée ; Complication ; Antiglaucomateux ; Récepteur α2-adrénergique ; Agoniste ; Brimonidine ; Lambeau ; Adhérence ; Hémorragie ; Prévention ; Chimioprophylaxie ;

Mots-clés espagnols / Spanish Keywords

Quinoxalina derivado ; Imidazol derivado ; Hombre ; Postoperatorio ; Queratomileusis ; In situ ; Laser ; Córnea ; Complicación ; Antiglaucomatoso ; Receptor α2-adrenérgico ; Agonista ; Brimonidina ; Colgajo ; Adherencia ; Hemorragia ; Prevención ; Quimioprofilaxis ;

Localisation / Location

INIST-CNRS, Cote INIST : 21122, 35400010900083.0100