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Titre du document / Document title

Elevada prevalencia de déficit de vitamina D en poblaciones con riesgo de osteoporosis: Un factor relevante en la integridad Ósea = Prevalence of vitamin D deficiency in populations at risk for osteoporosis: impact on bone integrity

Auteur(s) / Author(s)

MEZQUITA RAYA Pedro ; MUNOZ TORRES Manuel ; LOPEZ RODRIGUEZ Francisca ; MARTINEZ MARTIN Nuria ; CONDE VALERO Alicia ; ORTEGO CENTENO Norberto ; GONZALEZ CALVIN Jorge ; RAYA ALVAREZ Enrique ; DE DIOS LUNA Juan ; ESCOBAR JIMENEZ Fernando ;

Résumé / Abstract

Bagroumd: severe deficiency of vitamin D is not a common finding in most developed countries. However, the prevalence of vitamin D insufficiency is relatively high and it can contribute to the descent of bone mass in osteoporosis risk populations. The objective of our study was to evaluate the prevalence of vitamin D insufficiency in postmenopausal women (PMW), patients with inflammatory bowel disease (IBD) and corticosteroid-dependent asthmatic patients (CAP) and to analyze its relationship with bone mineral density (BMD) and calciotropic hormones. Patients AND Methods: studied 299 patients (PMW: 161; IBD: 61; CAP: 77). In all cases, serum levels of PTH and 250HD were determined and the BMD (DXA, Hologic QDR1000) in lumbar spine (LS) and femoral neck (FN) was measured. Results: Vitamin D insufficiency (250HD < 15 ng/ml) was observed in 39.1% patients with PMW, 70.7% patients with IBD and 44.2% patients with CAP. 250HD concentrations were lower in Ell patients (p = 0.003) and PTH concentrations were higher in MPM (p < 0.001). We found a negative correlation between PTH and 250HD in the overall group and this correlation persisted after considering each group separately. After adjusting for remaining variables, 250HD was found to be significantly associated with BMD at lumbar spine and/or femoral neck in the three groups. C In populations at risk of osteoporosis, there is a high prevalence of vitamin D insufficiency. This insufficiency has a significant effect on bone integrity.

Revue / Journal Title

Medicina clinica    ISSN  0025-7753 

Source / Source

2002, vol. 119, no3, pp. 85-89 [5 page(s) (article)]

Langue / Language

Espagnol

Editeur / Publisher

Elsevier, Barcelona, ESPAGNE  (1943) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 12388, 35400010189661.0020

Nº notice refdoc (ud4) : 13766320



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