Titre du document / Document title

Investigation of cyclobenzaprine hydrochloride release from oral osmotic delivery systems containing a water-swellable polymer

Auteur(s) / Author(s)

RAZAGHI Amir M. ⁽¹⁾ ; SCHWARTZ Joseph B. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Schering-Plough Technical Operations, 1011 Morris Ave., U-13 Trailer, Union, NJ 07083, ETATS-UNIS
⁽²⁾ University of the Sciences, Philadelphia College of Pharmacy, Philadelphia, PA 19104, ETATS-UNIS

Résumé / Abstract

Oral osmotie delivery systems containing polyethylene oxide (PEO, a water-swellable polymer) were designed and the release of cyclobenzaprine hydrochloride (model drug) from the devices was investigated. The systems consisted of model drug, mannitol (osmotic agent). and increasing amounts of PEO surrounded by a semipermeable membrane drilled with a delivery orifice. There was a decrease in drug release rate with PEO in the core. This may be due to solubility-modulating properties of the polymer. Visual inspection of the devices with PEO showed significant swelling during dissolution testing. Swelling (internal pressure) may influence water imbibition rate into the core and subsequently drug release rate. The release rates were a function of membrane thickness. The release rates were independent of orifice size (range of 150-510 μm diameter) and hydrodynamic conditions for the devices. This would he advantageous in the delivery of drugs in man.

Revue / Journal Title

Drug development and industrial pharmacy   ISSN 0363-9045 

Source / Source

2002, vol. 28, n^o6, pp. 631-639 (15 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Colchester, ROYAUME-UNI  (1977) (Revue)

Mots-clés anglais / English Keywords

Cellulose acetate ; Coated tablet ; Tricyclic compound ; Dissolution ; Swelling ; Active ingredient ; Physicochemical properties ; In vitro ; Release ; Drug adjuvant ; Mannitol ; Controlled release form ; Ethylene oxide polymer ; Cyclobenzaprine ; Oral form ; Osmotic pump ; Control release polymer ; Drug carrier ; Dosage form ; Pharmaceutical technology ;

Mots-clés français / French Keywords

Cellulose acétate ; Comprimé enrobé ; Composé tricyclique ; Dissolution ; Gonflement ; Principe actif ; Propriété physicochimique ; In vitro ; Libération ; Adjuvant médicamenteux ; Mannitol ; Forme libération contrôlée ; Ethylène oxyde polymère ; Cyclobenzaprine ; Forme orale ; Pompe osmotique ; Polymère vecteur ; Vecteur médicament ; Forme pharmaceutique ; Technologie pharmaceutique ;

Mots-clés espagnols / Spanish Keywords

Celulosa acetato ; Tableta cubierta ; Compuesto tricíclico ; Disolución ; Inflamiento ; Principio activo ; Propiedad fisicoquímica ; In vitro ; Liberación ; Coadyuvante medicamentoso ; Manitol ; Forma liberación controlada ; Etileno óxido polímero ; Ciclobenzaprina ; Forma oral ; Bomba osmótica ; Polímero vector ; Vector medicamento ; Forma farmacéutica ; Tecnología farmacéutica ;

Localisation / Location

INIST-CNRS, Cote INIST : 17132, 35400010119148.0020