RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Furfuril palmitato: Un nuovo antiossidante topico efficace nel trattamento di dermatiti eczematose = Furfuryl palmitate: A new topical anti-oxidant effective in the treatment of dermatitis with eczema

Auteur(s) / Author(s)

BOCCHIETTO E. ; PECIS L. ; LISI P. ; ANGELINI G. ; AYALA F. ; BALATO N. ; BONAMONTE D. ; CAMPLONE G. ; FABRIZI G. ; MARZATICO F. ; NEMELKA O. ; PIGATTO P. ;

Résumé / Abstract

Background. In this work we present the results of a multi-center clinical investigation carried out on a new topical product (Triderm® Lenil+) containing Superoxide dismutase (SOD), 18-beta glycyrrethic acid and a new patented antioxidant molecule, Furfuryl palmitate. These actives principles altogether protect skin from cell damages that promote the inflammatory syndrome; their action is furthermore sustained by agents such as phytosphingosine and phytosterols which act to repair the skin barrier. Furfuryl palmitate is an ester with a strong quenching ability towards the singlet oxygene (1O2) and with a high permeability potential through the biological membranes, thanks to its lipophylic formula. Further than being among the main responsible for skin ageing, the 1O2 is involved in the genesis of many topical pathologies such as allergic and irritant dermatitis, atopic dermatitis, inflammation, psoriasis and sunburns. Methods. The absence of skin irritation and of pro-sensitising potential by the tested product have been investigated through a 48 h patch test on healthy volunteers and through an in vitro test on keratinocytes cultures. The product has been extensively tested for its effectiveness and skin tolerability on a selected population of adult and child patients suffering with atopic dermatitis, irritant and allergic contact dermatitis and seborrheic dermatitis. In a multi-center investigation, 108 cases have been analysed, 44 of which were of paediatric interest, with an age range from 2 months to 64 years. Results. The topical employ of Furfuryl palmitate causes a significant improvement of the inflammatory skin condition, with evident and fast inflammation and eczema reduction, as shown in the present study. Conclusions. The conclusion is drawn that this product proved to be very useful in the topical treatment of many skin diseases. , No side effects have been observed and its easy use is underlined.

Revue / Journal Title

Giornale italiano di dermatologia e venereologia    ISSN  0392-0488 

Source / Source

2002, vol. 137, no2, pp. 1-13, SUP2 [13 page(s) (article)]

Langue / Language

Italien
Revue : Multilingue

Editeur / Publisher

Minerva medica, Torino, ITALIE  (1980) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 7397, 35400010179373.0010

Nº notice refdoc (ud4) : 13758090



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas