Titre du document / Document title

Effects of low frequency electromagnetic fields on pineal melatonin in mouse

Auteur(s) / Author(s)

MANDA Dana ; IONESCU Mariana ; VLADOIU Suzana ; IANAS Olga ;

Résumé / Abstract

Pineal gland has been most frequently studied as a neuroendocrine response to low frequency electromagnetic fields (ELF) exposure. It has been clearly demonstrated that the pineal gland, via its daily pattern of melatoninsecretion, is involved in the mechanism of integration of the photoperiodic information. Melatonin synthesis and NAT activity in the pineal gland exhibit strong circadian rhythms in mammals including man. Thus, melatonin synthesis and secretion occur during the dark period of the light/dark cycle and the duration of this secretion is directly dependent upon the duration of the dark phase. Besides visible radiation (400-720) and UV, extremely low frequency electromagnetic fields can alter the normal periodicity of MLT synthesis and secretion. The purpose of this study was to determine whether the exposure to 50 and 100 Hz pulsed electromagnetic field (PELF) could influence serum melatonin concentration. A²G male mice have been exposed to pulsed electromagnetic field for 21 days or 1 day. Pineal glands were removed and ultrasonicated. Both pineal melatonin and protein were assayed. The exposure of animals for 21 days dramatically attenuated the rise in nocturnal melatonin while the acute exposure reduced the nocturnal pineal concentrations to the diurnal levels. One week after the PELF exposure the normal circadian rhythm was re-established.

Revue / Journal Title

Romanian journal of endocrinology    ISSN  1221-356X 

Source / Source

2000, vol. 38, n^o1-2, pp. 11-16 [6 page(s) (article)]

Langue / Language

Anglais
Revue : Multilingue

Editeur / Publisher

Editura Academiei Române, Bucuresti,   (1992) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 11776, 35400010152289.0020