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Titre du document / Document title

Muscle inflammatory cells after passive stretches, isometric contractions, and lengthening contractions

Auteur(s) / Author(s)

PIZZA Francis X. (1) ; KOH Timothy J. (2) ; MCGREGOR Stephen J. (1) ; BROOKS Susan V. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Kinesiology, The University of Toledo, Toledo, Ohio 43606-3390, ETATS-UNIS
(2) Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109-2007, ETATS-UNIS

Résumé / Abstract

We tested the hypotheses that lengthening contractions, isometric contractions, and passive stretches increase muscle inflammatory cells (neutrophils and macrophages) and that prior conditioning with lengthening contractions, isometric contractions, or passive stretches reduces neutrophils and macrophages after subsequent lengthening contractions. Extensor digitorum longus muscles in anesthetized mice were subjected in situ to lengthening contractions, isometric contractions, or passive stretches. Six hours or 3 days after a protocol of contractions or passive stretches, neutrophils and macrophages were quantified in muscle cross sections. Three days after isometric contractions or passive stretches, neutrophils were elevated (P < 0.05) 3.7- and 5.5-fold, respectively, relative to controls. Both macrophages and neutrophils were increased 51.2- and 7.9-fold, respectively, after lengthening contractions. Prior lengthening contractions, isometric contractions, or passive stretches reduced inflammatory cells after lengthening contractions performed 2 wk later. The major finding of this study was that passive stretches and isometric contractions elevated neutrophils without causing overt signs of injury. Because both passive stretches and isometric contractions elevated neutrophils and afforded some protection from contraction-induced muscle injury, neutrophils and/or the related inflammatory events may contribute to the induction of a protective mechanism.

Revue / Journal Title

Journal of applied physiology    ISSN  8750-7587   CODEN JAPHEV 

Source / Source

2002, vol. 92, no5, pp. 1873-1878 (37 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Physiological Society, Bethesda, MD, ETATS-UNIS  (1985) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Striated muscle disease

;

Mouse

;

Macrophage

;

Neutrophil

;

Inflammation

;

Myocyte

;

Striated muscle

;

Degeneration

;

Stretching

;

Isometric muscular contraction

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Muscle strié pathologie

;

Souris

;

Macrophage

;

Neutrophile

;

Inflammation

;

Myocyte

;

Muscle strié

;

Dégénérescence

;

Etirement

;

Contraction musculaire isométrique

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Músculo estriado patología

;

Ratón

;

Macrófago

;

Neutrófilo

;

Inflamación

;

Miocito

;

Músculo estriado

;

Degeneración

;

Estiramiento

;

Contracción muscular isométrica

;

Localisation / Location

INIST-CNRS, Cote INIST : 5400, 35400010062934.0140

Nº notice refdoc (ud4) : 13650659



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