RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Antioxidant/restorative effects of calcined gold preparations used in Indian systems of medicine against global and focal models of ischaemia

Auteur(s) / Author(s)

ZAHOOR AHMAD SHAH (1) ; SHASHI BHARAT VOHORA (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, INDE

Résumé / Abstract

Stroke, or ischaemic brain damage, is of great geriatric importance being the third most common cause of death after cancer and heart diseases in developed countries. Despite such high frequency, its management has received inadequate attention. Many studies have shown the role of free radicals in the pathogenesis of ischaemic brain damage. Search for safe and effective antioxidant and free radial scavenger agents, therefore, appear to be a promising approach for stroke therapy. Gold, widely used in modern medicine for the treatment of rheumatoid arthritis, is highly valued for various medicinal uses in Indian systems of medicine. Traditional gold preparations are attributed with tonic/rejuvenating and antioxidant properties. Our earlier studies revealed interesting analgesic, immunostimulant, adaptogenic and glycogen sparing properties in these preparations, but their effects in cerebral ischaemia have not been investigated. This prompted us to initiate the present study using global and focal models of ischaemia in albino rats. Enzymatic parameters (lipid peroxidase, reduced glutathione, catalase, glutathione reductase, glutathione-S-transferase, glutatione peroxidase, superoxide dismutase, and glucose-6-phosphate dehydrogenase) were employed to assess ischaemic brain damage and its modulation. Significant restoration of altered values to near normal levels by Ayurvedic Swarna Bhasma and Unani Kushta Tila Kalan (25 mg/kg, orally for 10 days), suggest potentials for gold preparations in cerebrovascular diseases. The preparations deserve more scientific attention for possible therapeutic exploitation.

Revue / Journal Title

Pharmacology & toxicology    ISSN  0901-9928   CODEN PHTOEH 

Source / Source

2002, vol. 90, no5, pp. 254-259 (40 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1987-2003) (Revue)

Mots-clés anglais / English Keywords

Vascular disease

;

Cardiovascular disease

;

Cerebrovascular disease

;

Cerebral disorder

;

Central nervous system disease

;

Nervous system diseases

;

Asia

;

Vertebrata

;

Mammalia

;

Rodentia

;

Biological activity

;

Treatment efficiency

;

Oral administration

;

India

;

Folk medicine

;

Gold

;

Rat

;

Animal

;

Neuroprotective agent

;

Antioxidant

;

Radical scavenger

;

Oxygen

;

Brain (vertebrata)

;

Ischemia

;

Free radical

;

Treatment

;

Chemotherapy

;

Mots-clés français / French Keywords

Vaisseau sanguin pathologie

;

Appareil circulatoire pathologie

;

Cérébrovasculaire pathologie

;

Encéphale pathologie

;

Système nerveux central pathologie

;

Système nerveux pathologie

;

Asie

;

Vertebrata

;

Mammalia

;

Rodentia

;

Activité biologique

;

Efficacité traitement

;

Voie orale

;

Inde

;

Médecine traditionnelle

;

Or

;

Rat

;

Animal

;

Neuroprotecteur

;

Antioxydant

;

Intercepteur radical

;

Oxygène

;

Encéphale

;

Ischémie

;

Radical libre

;

Traitement

;

Chimiothérapie

;

Mots-clés espagnols / Spanish Keywords

Vaso sanguíneo patología

;

Aparato circulatorio patología

;

Vaso sanguíneo encéfalo patología

;

Encéfalo patología

;

Sistema nervosio central patología

;

Sistema nervioso patología

;

Asia

;

Vertebrata

;

Mammalia

;

Rodentia

;

Actividad biológica

;

Eficacia tratamiento

;

Vía oral

;

India

;

Medicina tradicional

;

Oro

;

Rata

;

Animal

;

Neuroprotector

;

Antioxidante

;

Interceptor radical

;

Oxígeno

;

Encéfalo

;

Isquemia

;

Radical libre

;

Tratamiento

;

Quimioterapia

;

Localisation / Location

INIST-CNRS, Cote INIST : 3119, 35400010123306.0040

Nº notice refdoc (ud4) : 13640276



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas