Titre du document / Document title

Lymecycline and minocycline in inflammatory acne: A randomized, double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy

Auteur(s) / Author(s)

PIERARD-FRANCHIMONT Claudine ⁽¹⁾ ; GOFFIN Véronique ⁽¹⁾ ; ARRESE Jorge E. ⁽¹⁾ ; MARTALO Oriane ⁽¹⁾ ; BRAHAM Catherine ⁽¹⁾ ; SLACHMUYLDERS Patricia ⁽²⁾ ; PIERARD Gérald E. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Dermatopathology, University Medical Center Sart Tilman, Liège, BELGIQUE
⁽²⁾ Wyeth Lederle Medical Department, Louvain-La-Neuve, BELGIQUE

Résumé / Abstract

Background: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. Aim: To evaluate the clinical and in vivo antibacterial effect of lymecycline and minocycline at different dosages. Method: Eighty-six patients with moderate to severe acne were enrolled in a randomized, double-blind, intent-to-treat study comparing in three parallel groups the effect of (1) lymecycline 300 mg daily for 12 weeks, (2) minocycline 50 mg daily for 12 weeks and (3) minocycline 100 mg daily for 4 weeks followed by 50 mg daily for 8 weeks. Evaluations were made at the screening visit and at five on-treatment visits. They consisted of clinical counts of acne lesions and evaluations of bacterial viability using dual flow cytometry performed on microorganisms collected from sebaceous infundibula by cyanoacrylate strippings. Results: Patients receiving minocycline 100/50 mg had the best clinical outcome, particularly in the reduction of the number of papules. By the end of the trial, the microbial response to minocycline 100/ 50 mg was also superior to either of the other two treatments. There were less live and more dead bacteria. Conclusion: In this trial, minocycline 100/50 mg was superior for the treatment of inflammatory acne when compared to lymecycline 300 mg and minocycline 50 mg.

Revue / Journal Title

Skin pharmacology and applied skin physiology   ISSN 1422-2868 

Source / Source

2002, vol. 15, n^o2, pp. 112-119 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Karger, Basel, SUISSE  (1998) (Revue)

Mots-clés anglais / English Keywords

Skin disease ; Tetracycline derivatives ; Oral administration ; Placebo ; Double blind study ; Randomization ; Human ; Dose activity relation ; Comparative study ; Treatment efficiency ; Treatment ; Acne vulgaris ; Chemotherapy ; Minocycline ; Antibacterial agent ; Antibiotic ; Lymecycline ;

Mots-clés français / French Keywords

Peau pathologie ; Tétracycline dérivé ; Voie orale ; Placebo ; Etude double insu ; Randomisation ; Homme ; Relation dose réponse ; Etude comparative ; Efficacité traitement ; Traitement ; Acné vulgaire ; Chimiothérapie ; Minocycline ; Antibactérien ; Antibiotique ; Lymécycline ;

Mots-clés espagnols / Spanish Keywords

Piel patología ; Tetraciclina derivado ; Vía oral ; Placebo ; Estudio doble ciego ; Aleatorización ; Hombre ; Relación dosis respuesta ; Estudio comparativo ; Eficacia tratamiento ; Tratamiento ; Acné vulgar ; Quimioterapia ; Minociclina ; Antibacteriano ; Antibiótico ; Limeciclina ;

Localisation / Location

INIST-CNRS, Cote INIST : 21743, 35400010052935.0060