Titre du document / Document title

A randomized placebo controlled trial of Inolter (herbal product) in the treatment of type 2 diabetes

Auteur(s) / Author(s)

AGRAWAL R. P. ; SHARMA Aradhana ; DUA A. S. ; CHANDERSHEKHAR ; KOCHAR D. K. ; KOTHARI R. P. ;

Résumé / Abstract

Objective: To evaluate the safety and effectiveness of Inolter in achieving glycemic control and changes in lipid profile of newly diagnosed type 2 diabetics. Material and Methods: Study design: A randomized, placebo-controlled double blind. Sixty newly diagnosed patients of type-2 diabetes were randomized. Of these, 30 were put on Inolter monotherapy and 30 patients on placebo. Efficacy of inolter was determined by observing glycemic control by estimating glycosylated haemoglobin (HbA^1c) and fasting blood sugar (FBS), alteration of lipid profile by serum cholesterol, LDL, VLDL, HDL and triglycerides. Statistical Methods: Student's unpaired t' test. Results: Patients compliance was satisfactory and no adverse effects were observed. Better hypoglycemic effect was observed with inolter both respect to fasting blood sugar (mean 65.4 ′ 63.72 mg/dl) compared to placebo (mean 26.45 ′ 38.3 mgldl) (p < 0.001). The mean change, with Inolter, in serum cholesterol (21.33 ′ 26.05 mg/dl), serum triglyceride (30.36 ′ 32.62 mg/dl), VLDL (8.85 ′ 3.25 mg/dl), LDL (10.00 ′ 4.48 mg/dl) and HDL (-2.33 ′ 5.66 mg/dl) was also significantly different (p < 0.001) from those given placebo, where it was 15.7 ′ 20.14 mg/dl, 8.70 ′ 13.24, 0.10 ′ 4.10 mg/dl, -0.70 ′ 4.58 mg/dl and 0.65 ′ 0.00 mg/dl, respectively. Conclusion: Inolter appears to be an useful adjunctive therapy to exercise and diet control in newly diagnosed type 2 diabetes mellitus.

Revue / Journal Title

Journal of Association of Physicians of India   ISSN 0004-5772 

Source / Source

2002, vol. 50, n^oMAR, pp. 391-393 [3 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Association of Physicians of India, Bombay, INDE  (1953) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 19760, 35400010054154.0040