Titre du document / Document title

Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16

Auteur(s) / Author(s)

DORSEY Susan G. ; BAMBRICK Linda L. ; BALICE-GORDON Rita J. ; KRUEGER Bruce K. ;

Résumé / Abstract

The neurotrophin, brain derived neurotrophic factor (BDNF), exerts multiple effects on the development and maintenance of the nervous system, including regulating synaptic plasticity and promoting neuron survival. Here wereport the selective failure of BDNF-dependent survival in cultured hippocampal neurons from the trisomy 16 (Ts16) mouse, an animal model of Down syndrome. This failure is accompanied by overexpression of a truncated, kinase-deficient isoform (T1) of the BDNF receptor tyrosine receptor kinase B (trkB). Adenovirus-mediated introduction of exogenous full-length trkB into Ts16 neurons fully restored BDNF-dependent survival, whereas exogenous truncated trkB expression in normal, euploid neurons reproduced the Ts16 BDNF signaling failure. Thus, the failure of Ts16 neurons to respond to BDNF is caused by dysregulation of trkB isoform expression. Such a neurotrophin signaling defect could contribute to developmental and degenerative disorders of the nervous system.

Revue / Journal Title

The Journal of neuroscience    ISSN  0270-6474   CODEN JNRSDS 

Source / Source

2002, vol. 22, n^o7, pp. 2571-2578 [8 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Society for Neuroscience, Washington, DC, ETATS-UNIS  (1981) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 19153, 35400010049345.0190