RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Association between simian virus 40 and non-Hodgkin lymphoma

Auteur(s) / Author(s)

VILCHEZ Regis A. (1 2 3) ; MADDEN Charles R. (2) ; KOZINETZ Claudia A. (3 4) ; HALVORSON Steven J. (2) ; WHITE Zoe S. (2) ; JORGENSEN Jeffrey L. (5) ; FINCH Chris J. (5) ; BUTEL Janet S. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Medicine, Baylor College of Medicine, Houston, TX, ETATS-UNIS
(2) Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, ETATS-UNIS
(3) Baylor Center for AIDS Research, Baylor College of Medicine, Houston, TX, ETATS-UNIS
(4) Department of Pediatrics, Baylor College of Medicine, Houston, TX, ETATS-UNIS
(5) Department of Pathology, Baylor College of Medicine, Houston, TX, ETATS-UNIS

Résumé / Abstract

Background Non-Hodgkin lymphoma has increased in frequency over the past 30 years, and is a common cancer in HIV-1-infected patients. Although no definite risk factors have emerged, a viral cause has been postulated. Polyomaviruses are known to infect human beings and to induce tumours in laboratory animals. We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma. Methods We analysed systemic non-Hodgkin lymphoma from 76 HIV-1-infected and 78 HIV-1-uninfected patients, and non-malignant lymphoid samples from 79 HIV-1-positive and 107 HIV-1-negative patients without tumours; 54 colon and breast carcinoma samples served as cancer controls. We used PCR followed by Southern blot hybridisation and DNA sequence analysis to detect DNAs of polyomaviruses and herpesviruses. Findings Polyomavirus T antigen sequences, all of which were SV40-specific, were detected in 64 (42%) of 154 non-Hodgkin lymphomas, none of 186 non-malignant lymphoid samples, and none of 54 control cancers. This difference was similar for HIV-1-infected patients and HIV-1-uninfected patients alike. Few tumours were positive for both SV40 and Epstein-Barr virus. Human herpesvirus type 8 was not detected. SV40 sequences were found most frequently in diffuse large B-cell and follicular-type lymphomas. Interpretation SV40 is significantly associated with some types of non-Hodgkin lymphoma. These results add lymphomas to the types of human cancers associated with SV40.

Revue / Journal Title

Lancet    ISSN  0140-6736   CODEN LANCAO 

Source / Source

2002, vol. 359, no9309, pp. 817-823 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1823) (Revue)

Mots-clés anglais / English Keywords

Lymphoproliferative syndrome

;

Malignant hemopathy

;

Infection

;

Virus

;

Papovaviridae

;

Carcinogenesis

;

Oncogenic virus

;

Pathogenesis

;

Human

;

Viral disease

;

Simian virus 40

;

Polyomavirus

;

Non Hodgkin lymphoma

;

Mots-clés français / French Keywords

Lymphoprolifératif syndrome

;

Hémopathie maligne

;

Infection

;

Virus

;

Papovaviridae

;

Carcinogenèse

;

Virus oncogène

;

Pathogénie

;

Homme

;

Virose

;

Virus simien 40

;

Polyomavirus

;

Lymphome non hodgkinien

;

Mots-clés espagnols / Spanish Keywords

Linfoproliferativo síndrome

;

Hemopatía maligna

;

Infección

;

Virus

;

Papovaviridae

;

Carcinogénesis

;

Virus oncogénico

;

Patogenia

;

Hombre

;

Virosis

;

Simian virus 40

;

Polyomavirus

;

Linfoma no Hodgkin

;

Localisation / Location

INIST-CNRS, Cote INIST : 5004, 35400010080357.0050

Nº notice refdoc (ud4) : 13573250



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas