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Titre du document / Document title

Interactions between macrophages and brain microvascular endothelial cells : role in pathogenesis of HIV-1 infection and blood - brain barrier function

Auteur(s) / Author(s)

NOTTET H. S. L. M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Eijkman-Winkler Institute of Microbiology, Infectious Diseases and Inflammation, section of Neuroimmunology, Utrecht University, Utrecht, PAYS-BAS

Résumé / Abstract

Monocytes have been shown to infiltrate in brain tissue during various neurological disorders including AIDS dementia complex. The presence of an excess of activated macrophages in brain tissue is accompanied by tissue damage resulting in a loss in neuronal function and viability. Therapeutic options against such neurological disorders could therefore be aimed at the prevention of monocyte infiltration across the blood - brain barrier. Therefore, a better understanding of these processes is needed. Recent insights in cellular processes between monocytes/macrophages and brain microvascular endothelial cells in the neuropathogenesis of HIV-1 infection demonstrate that monocytes roll on endothelial cells via the inducible endothelial adhesion molecule E-selectin. Binding of these cells are mainly mediated via the endothelial adhesion molecule vascular cell adhesion molecule-1. The transmigration through the blood-brain barrier is facilitated by both endothelial and monocyte/macrophage-derived nitric oxide and by the increased production of gelatinase B activity by HIV-infected monocytes/ macrophages. Chemokines produced within the brain regulate the traffic of the infiltrating monocytes through the brain parenchyma. In addition, endothelial cells also produce monocyte attracting chemokines during their first interactions with HIV-infected monocytes/macrophages thus promoting additional influx of phagocytes into the brain. Furthermore, excessive infiltration of monocytes is accompanied by endothelial damage resulting in the loss of tight junctions. Thus, in toto, brain microvascular endothelial cells might contribute to the neuropathogenesis of HIV-1 infection.

Revue / Journal Title

Journal of neurovirology    ISSN  1355-0284 

Source / Source

1999, vol. 5, no 6 (172 p.)  (2 p.3/4), pp. 659-669

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1995) (Revue)

Mots-clés anglais / English Keywords

AIDS

;

HIV-1 virus

;

Cerebral disorder

;

Blood brain barrier

;

Endothelial cell

;

Microcirculation

;

Macrophage

;

Monocyte

;

Treatment

;

Pathogenesis

;

Complication

;

Cell cell interaction

;

Human

;

Viral disease

;

Infection

;

Human immunodeficiency virus

;

Lentivirus

;

Retroviridae

;

Virus

;

Immunopathology

;

Immune deficiency

;

Nervous system diseases

;

Central nervous system disease

;

Circulatory system

;

Blood vessel

;

Mots-clés français / French Keywords

SIDA

;

Virus HIV1

;

Encéphale pathologie

;

Barrière hématoencéphalique

;

Cellule endothéliale

;

Microcirculation

;

Macrophage

;

Monocyte

;

Traitement

;

Pathogénie

;

Complication

;

Interaction cellulaire

;

Homme

;

Virose

;

Infection

;

Virus immunodéficience humaine

;

Lentivirus

;

Retroviridae

;

Virus

;

Immunopathologie

;

Immunodéficit

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Appareil circulatoire

;

Vaisseau sanguin

;

Mots-clés espagnols / Spanish Keywords

SIDA

;

HIV-1 virus

;

Encéfalo patología

;

Barrera hematoencefálica

;

Célula endotelial

;

Microcirculación

;

Macrófago

;

Monocito

;

Tratamiento

;

Patogenia

;

Complicación

;

Interacción celular

;

Hombre

;

Virosis

;

Infección

;

Human immunodeficiency virus

;

Lentivirus

;

Retroviridae

;

Virus

;

Inmunopatología

;

Inmunodeficiencia

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Aparato circulatorio

;

Vaso sanguíneo

;

Localisation / Location

INIST-CNRS, Cote INIST : 26734, 35400008647837.0110

Nº notice refdoc (ud4) : 1353602



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