Titre du document / Document title

Myocardial infarction following the combined recreational use of Viagra® and cannabis

Auteur(s) / Author(s)

MCLEOD A. L. ⁽¹⁾ ; MCKENNA C. J. ⁽¹⁾ ; NORTHRIDGE D. B. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Cardiology, Western General Hospital, Edinburgh, ROYAUME-UNI

Résumé / Abstract

Sildenafil citrate (Viagra®, Pfizer, Inc., New York, N.Y.) is widely prescribed as a treatment for male erectile dysfunction. It is metabolized predominantly by the cytochrome P450 3A4 hepatic microsomal isoenzyme and effects can, therefore, be potentiated by such inhibitors. The vasodilatory effects of Viagra necessitate caution in its use in patients with cardiovascular disease and it is contraindicated in patients receiving nitrates. Previous literature has drawn attention to Viagra use and myocardial infarction. This paper reports the case of a young man who presented with a myocardial infarction after taking Viagra in combination with cannabis, a known inhibitor of the cytochrome P450 3A4 isoenzyme.

Revue / Journal Title

Clinical cardiology   ISSN 0160-9289   CODEN CLCADC 

Source / Source

2002, vol. 25, n^o3, pp. 133-134 (6 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Drug addiction ; Erection disorders ; Male genital diseases ; Myocardial disease ; Coronary heart disease ; Cardiovascular disease ; Spermatophyta ; Angiospermae ; Dicotyledones ; Cannabidaceae ; Vasodilator agent ; Case study ; Human ; Toxicity ; Drug combination ; Treatment ; Chemotherapy ; Inhibitor ; Cytochrome P450 ; Cannabis ; Impotence ; Sildenafil ; Myocardium ; Infarct ;

Mots-clés français / French Keywords

Toxicomanie ; Erection pathologie ; Appareil génital mâle pathologie ; Myocarde pathologie ; Cardiopathie coronaire ; Appareil circulatoire pathologie ; Spermatophyta ; Angiospermae ; Dicotyledones ; Cannabidaceae ; Vasodilatateur ; Etude cas ; Homme ; Toxicité ; Association médicamenteuse ; Traitement ; Chimiothérapie ; Inhibiteur ; Cytochrome P450 ; Cannabis ; Impuissance ; Sildénafil ; Myocarde ; Infarctus ;

Mots-clés espagnols / Spanish Keywords

Toxicomanía ; Erección patología ; Aparato genital macho patología ; Miocardio patología ; Cardiopatía coronaria ; Aparato circulatorio patología ; Spermatophyta ; Angiospermae ; Dicotyledones ; Cannabidaceae ; Vasodilatador ; Estudio caso ; Hombre ; Toxicidad ; Asociación medicamentosa ; Tratamiento ; Quimioterapia ; Inhibidor ; Citocromo P450 ; Cannabis ; Impotencia ; Sildenafilo ; Miocardio ; Infarto ;

Localisation / Location

INIST-CNRS, Cote INIST : 19682, 35400010034636.0070