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Titre du document / Document title

Progesterone induces apoptosis in malignant mesothelioma cells

Auteur(s) / Author(s)

HORITA Kouichi (1) ; INASE Naohiko (1) ; MIYAKE Shuji (1) ; FORMBY Bent (2) ; TOYODA Hiroo (3) ; YOSHIZAWA Yasuyuki (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) The Pulmonary Medicine, Tokyo Medical and Dental University, Tokyo, JAPON
(2) The Rasmus Institute for Medical Research, Santa Barbara, CA, ETATS-UNIS
(3) The Department of Anatomic Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, ETATS-UNIS

Résumé / Abstract

Progesterone has been used in the treatment of patients with recurrent or metastatic progesterone receptor-positive endometrial carcinoma and breast cancer. In vitro study using a breast cancer cell line, T47D, demonstrated an increase in p53 gene expression and induction of apoptosis by the administration of progesterone. Therefore, we investigated the effect of progesterone administration on the proliferation and apoptosis in a mesothelioma cell line, 211H. The expression of the progesterone receptor gene was detected in this cell line by a nested RT-PCR method. The proliferation of the cell line was suppressed after a 10-day incubation with 30μM progesterone. In progesterone-treated 211H cells, apoptotic cells were detected by TUNEL assay and nuclear DNA fragmentation analysis. These results clearly demonstrated that progesterone administration suppressed the cell proliferation and induced apoptosis in malignant mesothelioma cells.

Revue / Journal Title

Anticancer research    ISSN  0250-7005 

Source / Source

2001, vol. 21, no6A, pp. 3871-3874 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

International Institute of Anticancer Research, Attiki, GRECE  (1980) (Revue)

Mots-clés anglais / English Keywords

Sex steroid hormone

;

Malignant tumor

;

Human

;

In vitro

;

Biological activity

;

Cell death

;

Apoptosis

;

Antineoplastic agent

;

Progesterone

;

Established cell line

;

Malignant mesothelioma

;

Mots-clés français / French Keywords

Hormone stéroïde sexuelle

;

Tumeur maligne

;

Lignée H2052

;

Lignée 211H

;

Lignée H28

;

Homme

;

In vitro

;

Activité biologique

;

Mort cellulaire

;

Apoptose

;

Anticancéreux

;

Progestérone

;

Lignée cellulaire établie

;

Mésothéliome malin

;

Mots-clés espagnols / Spanish Keywords

Hormona esteroide sexual

;

Tumor maligno

;

Hombre

;

In vitro

;

Actividad biológica

;

Muerte celular

;

Apoptosis

;

Anticanceroso

;

Progesterona

;

Línea celular establecida

;

Mesotelioma maligno

;

Localisation / Location

INIST-CNRS, Cote INIST : 19426, 35400010263557.0220

Nº notice refdoc (ud4) : 13522077



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