Titre du document / Document title

A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding

Auteur(s) / Author(s)

THÖRNE A. ⁽¹⁾ ; LÖNNQVIST F. ⁽²⁾ ; APELMAN J. ⁽¹⁾ ; HELLERS G. ⁽¹⁾ ; ARNER P. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Surgery, Karolinska Institute at Huddinge University Hospital, Stockholm, SUEDE
⁽²⁾ Department of Medicine, Karolinska Institute at Huddinge University Hospital, Stockholm, SUEDE

Résumé / Abstract

AIM: To determine whether visceral fat reduction in connection with bariatric surgery could improve weight loss and metabolic profile of obese subjects. PATIENTS AND METHODS: In a one-center, randomized and controlled pilot trial we assigned 50 subjects with severe obesity (body mass index >35 kg/m²) to either adjustable gastric banding (AGB) alone (11 men and 14 women), or AGB plus surgical removal of the total greater omentum (11 men and 14 women). The patients were followed at regular intervals for 2y and examined at 0 and 24 months with respect to body composition and metabolic profile. RESULTS: No significant differences between control and omentectomized patients were observed at baseline. The removed greater omentum constituted 0.8±0.4% (mean ± s.d.) of total body fat. At 2y follow-up there was an expected decrease in body weight and an improvement in metabolic profile in both groups. Although omentectomized subjects tended to lose more weight than control subjects the difference was not statistically significant and changes in waist-to-hip ratio and saggital diameter did not differ between groups. However, the improvements in oral glucose tolerance, insulin sensitivity and fasting plasma glucose and insulin were 2-3 times greater in omentectomized as compared to control subjects (P from 0.009 to 0.04), which was statistically independent of the loss in body mass index. No differences in blood lipids between the groups were recorded. No adverse effects related to omentectomy were observed. CONCLUSIONS: Omentectomy, when performed together with AGB, has significant positive and long-term effects on the glucose and insulin metabolic profiles in obese subjects.

Revue / Journal Title

International journal of obesity   ISSN 0307-0565   CODEN IJOBDP 

Source / Source

2002, vol. 26, n^o2, pp. 193-199 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1977) (Revue)

Mots-clés anglais / English Keywords

Nutrition disorder ; Body composition ; Female ; Severe ; Nutritional status ; Randomization ; Human ; Visceral fat ; Treatment ; Long term ; Waist hip ratio ; Body weight ; Fat ; Weight loss ; Omentum ; Body mass index ; Stomach ; Surgery ; Obesity ;

Mots-clés français / French Keywords

Trouble nutrition ; Composition corporelle ; Femelle ; Grave ; Etat nutritionnel ; Randomisation ; Homme ; Graisse viscérale ; Traitement ; Long terme ; Rapport taille-hanche ; Poids corporel ; Matière grasse ; Perte poids ; Epiploon ; Indice masse corporelle ; Estomac ; Chirurgie ; Obésité ;

Mots-clés espagnols / Spanish Keywords

Trastorno nutricíon ; Composicíon corporal ; Hembra ; Grave ; Estado nutricional ; Aleatorización ; Hombre ; Grasa visceral ; Tratamiento ; Largo plazo ; Relación cintura cadera ; Peso corporal ; Materia grasa ; Adelgazamiento ; Epiplón ; Indice masa corporal ; Estómago ; Cirugía ; Obesidad ;

Localisation / Location

INIST-CNRS, Cote INIST : 18243, 35400010262146.0070